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The pathophysiology and immunology of axial spondyloarthritis 

The pathophysiology and immunology of axial spondyloarthritis
The pathophysiology and immunology of axial spondyloarthritis

Stefan Siebert

, Sengupta Raj

, and Alexander Tsoukas

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date: 23 September 2020

Ankylosing spondylitis (AS) is a heterogeneous and complex disease. While the exact pathophysiology remains unclear, significant advances have recently been made in the understanding of several implicated processes. The potential role and interplay of genetic susceptibility, biomechanics, the microbiome, and key cytokines in axial spondyloarthritis (axSpA) is described in this chapter, with particular focus on the IL-23/IL-17 pathway.

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