- Foreword
- Abbreviations
- Contributors
- Chapter 1 The current classification of bipolar disorders
- Chapter 2 Should the bipolar disorders be modelled dimensionally or categorically?
- Chapter 3 The treatment of bipolar disorder in its early stages: current techniques, challenges, and future outlook
- Chapter 4 Evidence-based treatment of mania
- Chapter 5 The treatment of bipolar mixed states
- Chapter 6 The treatment of rapid cycling bipolar disorder
- Chapter 7 Evidence-based treatment of bipolar depression
- Chapter 8 Evidence-based maintenance treatment of bipolar disorder
- Chapter 9 The treatment of bipolar II disorder
- Chapter 10 The treatment of cyclothymia
- Chapter 11 Psychological interventions for early stage bipolar disorder
- Chapter 12 Psychotherapeutic interventions for bipolar disorder
- Chapter 13 The role of psychoeducation in the management of bipolar disorder
- Chapter 14 Functional remediation therapy for bipolar disorder
- Chapter 15 Predominant polarity, polarity index, and treatment selection in bipolar disorder
- Chapter 16 The assessment and management of suicide risk in bipolar disorder
- Chapter 17 Treatment implications for bipolar disorder co-occurring with anxiety syndromes and substance abuse
- Chapter 18 The impact of psychiatric co-morbidity in the treatment of bipolar disorder: focus on co-occurring attention deficit hyperactivity disorder and eating disorders
- Chapter 19 Bidirectional relationships between general medical conditions and bipolar disorder: treatment considerations
- Chapter 20 The treatment of bipolar disorder in women
- Chapter 21 The treatment of bipolar disorder in children and adolescents
- Chapter 22 The treatment of bipolar disorder in the elderly
- Chapter 23 The management of treatment-resistant bipolar disorder
- Chapter 24 Staging and neuroprogression in bipolar disorder: treatment implications
- Chapter 25 Pharmacotherapy of bipolar disorder: impact on neurocognition
- Chapter 26 Cognitive enhancement in bipolar disorder: current evidence and methodological considerations
- Chapter 27 The role of electroconvulsive therapy in the treatment of bipolar disorder
- Chapter 28 Neuromodulatory approaches for bipolar disorder: current evidences and future perspectives
- Chapter 29 The role of complementary and alternative therapies for the management of bipolar disorder
- Chapter 30 Novel therapeutic targets for bipolar disorder
- Chapter 31 The treatment of bipolar disorder in the era of personalized medicine: myth or promise?
- Index
(p. 357) Staging and neuroprogression in bipolar disorder: treatment implications
- Chapter:
- (p. 357) Staging and neuroprogression in bipolar disorder: treatment implications
- Author(s):
Ives Cavalcante Passos
and Flávio Kapczinski
- DOI:
- 10.1093/med/9780198748625.003.0024
It is known that if, not all, a substantial proportion of patients with bipolar disorder (BD) present a progressive course with functional and cognitive impairment. In addition, patients with BD and multiple mood episodes have a worse response to lithium and cognitive behaviour therapy. However, many current treatment guidelines do not take these clinical features that change with illness progression into account. In order to clarify these clinical questions, the term ‘neuroprogression’ was conceptualized as the pathological rewiring of the brain that takes place in parallel with the clinical deterioration in the course of BD. It provides a heuristic basis for conceptualizing the biochemical foundation of changes in brain circuits related to the progressive course of BD. Herein, we aim to review risk factors, biological underpinnings, and treatment implications related to neuroprogression in BD.
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- Foreword
- Abbreviations
- Contributors
- Chapter 1 The current classification of bipolar disorders
- Chapter 2 Should the bipolar disorders be modelled dimensionally or categorically?
- Chapter 3 The treatment of bipolar disorder in its early stages: current techniques, challenges, and future outlook
- Chapter 4 Evidence-based treatment of mania
- Chapter 5 The treatment of bipolar mixed states
- Chapter 6 The treatment of rapid cycling bipolar disorder
- Chapter 7 Evidence-based treatment of bipolar depression
- Chapter 8 Evidence-based maintenance treatment of bipolar disorder
- Chapter 9 The treatment of bipolar II disorder
- Chapter 10 The treatment of cyclothymia
- Chapter 11 Psychological interventions for early stage bipolar disorder
- Chapter 12 Psychotherapeutic interventions for bipolar disorder
- Chapter 13 The role of psychoeducation in the management of bipolar disorder
- Chapter 14 Functional remediation therapy for bipolar disorder
- Chapter 15 Predominant polarity, polarity index, and treatment selection in bipolar disorder
- Chapter 16 The assessment and management of suicide risk in bipolar disorder
- Chapter 17 Treatment implications for bipolar disorder co-occurring with anxiety syndromes and substance abuse
- Chapter 18 The impact of psychiatric co-morbidity in the treatment of bipolar disorder: focus on co-occurring attention deficit hyperactivity disorder and eating disorders
- Chapter 19 Bidirectional relationships between general medical conditions and bipolar disorder: treatment considerations
- Chapter 20 The treatment of bipolar disorder in women
- Chapter 21 The treatment of bipolar disorder in children and adolescents
- Chapter 22 The treatment of bipolar disorder in the elderly
- Chapter 23 The management of treatment-resistant bipolar disorder
- Chapter 24 Staging and neuroprogression in bipolar disorder: treatment implications
- Chapter 25 Pharmacotherapy of bipolar disorder: impact on neurocognition
- Chapter 26 Cognitive enhancement in bipolar disorder: current evidence and methodological considerations
- Chapter 27 The role of electroconvulsive therapy in the treatment of bipolar disorder
- Chapter 28 Neuromodulatory approaches for bipolar disorder: current evidences and future perspectives
- Chapter 29 The role of complementary and alternative therapies for the management of bipolar disorder
- Chapter 30 Novel therapeutic targets for bipolar disorder
- Chapter 31 The treatment of bipolar disorder in the era of personalized medicine: myth or promise?
- Index