- Foreword
- Abbreviations
- Contributors
- Chapter 1 The current classification of bipolar disorders
- Chapter 2 Should the bipolar disorders be modelled dimensionally or categorically?
- Chapter 3 The treatment of bipolar disorder in its early stages: current techniques, challenges, and future outlook
- Chapter 4 Evidence-based treatment of mania
- Chapter 5 The treatment of bipolar mixed states
- Chapter 6 The treatment of rapid cycling bipolar disorder
- Chapter 7 Evidence-based treatment of bipolar depression
- Chapter 8 Evidence-based maintenance treatment of bipolar disorder
- Chapter 9 The treatment of bipolar II disorder
- Chapter 10 The treatment of cyclothymia
- Chapter 11 Psychological interventions for early stage bipolar disorder
- Chapter 12 Psychotherapeutic interventions for bipolar disorder
- Chapter 13 The role of psychoeducation in the management of bipolar disorder
- Chapter 14 Functional remediation therapy for bipolar disorder
- Chapter 15 Predominant polarity, polarity index, and treatment selection in bipolar disorder
- Chapter 16 The assessment and management of suicide risk in bipolar disorder
- Chapter 17 Treatment implications for bipolar disorder co-occurring with anxiety syndromes and substance abuse
- Chapter 18 The impact of psychiatric co-morbidity in the treatment of bipolar disorder: focus on co-occurring attention deficit hyperactivity disorder and eating disorders
- Chapter 19 Bidirectional relationships between general medical conditions and bipolar disorder: treatment considerations
- Chapter 20 The treatment of bipolar disorder in women
- Chapter 21 The treatment of bipolar disorder in children and adolescents
- Chapter 22 The treatment of bipolar disorder in the elderly
- Chapter 23 The management of treatment-resistant bipolar disorder
- Chapter 24 Staging and neuroprogression in bipolar disorder: treatment implications
- Chapter 25 Pharmacotherapy of bipolar disorder: impact on neurocognition
- Chapter 26 Cognitive enhancement in bipolar disorder: current evidence and methodological considerations
- Chapter 27 The role of electroconvulsive therapy in the treatment of bipolar disorder
- Chapter 28 Neuromodulatory approaches for bipolar disorder: current evidences and future perspectives
- Chapter 29 The role of complementary and alternative therapies for the management of bipolar disorder
- Chapter 30 Novel therapeutic targets for bipolar disorder
- Chapter 31 The treatment of bipolar disorder in the era of personalized medicine: myth or promise?
- Index
(p. 195) Predominant polarity, polarity index, and treatment selection in bipolar disorder
- Chapter:
- (p. 195) Predominant polarity, polarity index, and treatment selection in bipolar disorder
- Author(s):
Sabrina C. da Costa
, Joao L. de Quevedo
, and André F. Carvalho
- DOI:
- 10.1093/med/9780198748625.003.0015
Bipolar disorder (BD) is a chronic and disabling illness, with lifetime prevalence of 2.4% worldwide. Predominant polarity (PP), ie, depressive versus manic, may influence illness characteristics, treatment selection, and outcomes in BD. PP has been proposed as a course specifier for BD, although not included in the Diagnostic and Statistical Manual of Mental Disorders (5th edn) (DSM-5). The polarity index (PI), a metric algorithm that reflects antimanic versus antidepressant maintenance efficacy of available treatments for BD, is calculated as the ratio of number needed to treat (NNT) for prevention of depression and NNT for prevention of mania. Evidence indicates that the net PI of ongoing maintenance-treatment regimens for BD is related to the patient’s PP. Additionatlly, PP and PI may aid in treatment selection and outcome prediction in BD. Therefore, this chapter provides an overview of putative roles of PP and PI in the course and treatment selection for BD.
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- Foreword
- Abbreviations
- Contributors
- Chapter 1 The current classification of bipolar disorders
- Chapter 2 Should the bipolar disorders be modelled dimensionally or categorically?
- Chapter 3 The treatment of bipolar disorder in its early stages: current techniques, challenges, and future outlook
- Chapter 4 Evidence-based treatment of mania
- Chapter 5 The treatment of bipolar mixed states
- Chapter 6 The treatment of rapid cycling bipolar disorder
- Chapter 7 Evidence-based treatment of bipolar depression
- Chapter 8 Evidence-based maintenance treatment of bipolar disorder
- Chapter 9 The treatment of bipolar II disorder
- Chapter 10 The treatment of cyclothymia
- Chapter 11 Psychological interventions for early stage bipolar disorder
- Chapter 12 Psychotherapeutic interventions for bipolar disorder
- Chapter 13 The role of psychoeducation in the management of bipolar disorder
- Chapter 14 Functional remediation therapy for bipolar disorder
- Chapter 15 Predominant polarity, polarity index, and treatment selection in bipolar disorder
- Chapter 16 The assessment and management of suicide risk in bipolar disorder
- Chapter 17 Treatment implications for bipolar disorder co-occurring with anxiety syndromes and substance abuse
- Chapter 18 The impact of psychiatric co-morbidity in the treatment of bipolar disorder: focus on co-occurring attention deficit hyperactivity disorder and eating disorders
- Chapter 19 Bidirectional relationships between general medical conditions and bipolar disorder: treatment considerations
- Chapter 20 The treatment of bipolar disorder in women
- Chapter 21 The treatment of bipolar disorder in children and adolescents
- Chapter 22 The treatment of bipolar disorder in the elderly
- Chapter 23 The management of treatment-resistant bipolar disorder
- Chapter 24 Staging and neuroprogression in bipolar disorder: treatment implications
- Chapter 25 Pharmacotherapy of bipolar disorder: impact on neurocognition
- Chapter 26 Cognitive enhancement in bipolar disorder: current evidence and methodological considerations
- Chapter 27 The role of electroconvulsive therapy in the treatment of bipolar disorder
- Chapter 28 Neuromodulatory approaches for bipolar disorder: current evidences and future perspectives
- Chapter 29 The role of complementary and alternative therapies for the management of bipolar disorder
- Chapter 30 Novel therapeutic targets for bipolar disorder
- Chapter 31 The treatment of bipolar disorder in the era of personalized medicine: myth or promise?
- Index