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Cutaneous reactions to drugs 

Cutaneous reactions to drugs
Cutaneous reactions to drugs

Susan Burge

, Rubeta Matin

, and Dinny Wallis

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date: 26 October 2020

This chapter provides guidance to the recognition of cutaneous adverse drug reactions, with an overview of the mechanisms of drug reactions and sections devoted to different patterns of cutaneous reactions, e.g. erythematous, scaly, purpuric, pigmented, and bullous. Drug-induced hair and nail problems are considered. Two sections focus specifically on reactions to chemotherapy agents, including BRAF inhibitors, EDRF inhibitors, multikinase inhibitors, and mTOR inhibitors. Problems, such as chemotherapy-induced hand–foot skin reaction, neutrophilic eccrine hidradenitis, eccrine squamous metaplasia, and flagellate dermatitis, are discussed. A section is devoted to drugs that may induce skin diseases such as acne-like pustular eruptions, psoriasis, dermatomyositis subacute cutaneous lupus erythematosus, and lichen planus.

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