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Dengue 

Dengue
Chapter:
Dengue
Author(s):

Bridget Wills

, and Yee-Sin Leo

DOI:
10.1093/med/9780198746690.003.0090
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date: 02 March 2021

Dengue is the most important mosquito-borne viral infection to affect humans. It is an RNA virus in the Flavivirus genus, family Flaviviridae. There are four closely related but serologically distinct viral serotypes, all of which may cause disease. Following infection with one serotype there is lifelong immunity to that serotype but the possibility of more severe disease during a subsequent infection with a different serotype. The primary mosquito vector is Aedes aegypti. Recent estimates suggest around 100 million symptomatic, and many more asymptomatic, infections occur annually worldwide. The disease is hyperendemic in many large Asian cities, and is also a significant problem in the Pacific region and in the Americas.

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