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Skin and systemic diseases 

Skin and systemic diseases
Chapter:
Skin and systemic diseases
Author(s):

Clive B. Archer

, and Charles M.G. Archer

DOI:
10.1093/med/9780198746690.003.0564
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date: 25 February 2021

Dermatology is most interesting where it overlaps with general internal medicine. Skin lesions can be part of a systemic disease (e.g. in sarcoidosis or systemic lupus erythematosus), or they may be a manifestation of an underlying disease or process as in the case of acanthosis nigricans, which can be associated with either an underlying adenocarcinoma in older patients, or with insulin resistance and sometimes overt diabetes mellitus in younger obese patients. Sarcoid can affect the skin in numerous ways, as can diabetes mellitus and liver disease. Renal disease may affect the skin by causing pruritus, pigmentary changes, dryness, and calciphylaxis, and use of immunosuppression can lead to an increase in malignancy in some cases. Common associations of pyoderma gangrenosum include inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), rheumatoid arthritis and other rheumatological disease, haematological malignancies, and monoclonal gammopathies.

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