Show Summary Details
Page of

Skin and systemic diseases 

Skin and systemic diseases
Skin and systemic diseases

Clive B. Archer

, and Charles M.G. Archer

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 25 February 2021

Dermatology is most interesting where it overlaps with general internal medicine. Skin lesions can be part of a systemic disease (e.g. in sarcoidosis or systemic lupus erythematosus), or they may be a manifestation of an underlying disease or process as in the case of acanthosis nigricans, which can be associated with either an underlying adenocarcinoma in older patients, or with insulin resistance and sometimes overt diabetes mellitus in younger obese patients. Sarcoid can affect the skin in numerous ways, as can diabetes mellitus and liver disease. Renal disease may affect the skin by causing pruritus, pigmentary changes, dryness, and calciphylaxis, and use of immunosuppression can lead to an increase in malignancy in some cases. Common associations of pyoderma gangrenosum include inflammatory bowel diseases (ulcerative colitis and Crohn’s disease), rheumatoid arthritis and other rheumatological disease, haematological malignancies, and monoclonal gammopathies.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.