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Autoimmune bullous diseases 

Autoimmune bullous diseases
Chapter:
Autoimmune bullous diseases
Author(s):

Kathy Taghipour

, and Fenella Wojnarowska

DOI:
10.1093/med/9780198746690.003.0553
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date: 07 March 2021

Autoimmune bullous diseases of the skin are a heterogenous group of blistering diseases that affect the skin and/or mucosal membranes. They are associated with significant morbidity and mortality and may present to several different specialists. They are broadly divided into two groups depending on the location of the blisters formed in the skin, which may be subepidermal (pemphigoids, linear IgA disease, dermatitis herpetiformis, epidermolysis bullosa acquisita) or intraepidermal (pemphigus group). Pathogenic autoantibodies (IgG, IgA) target either the proteins that provide keratinocyte adhesion (intraepidermal disease) or the proteins of hemidesmosomes that attach the basal cell layer to the basement membrane zone (subepidermal disease).

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