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Anaemia of inflammation 

Anaemia of inflammation
Anaemia of inflammation

Sant-Rayn Pasricha

, and Hal Drakesmith

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date: 28 February 2021

The anaemia of inflammation is one of the commonest causes of anaemia, particularly in the elderly and in those with extensive comorbidities. Dysregulation of the hepcidin axis is central to its pathophysiology, with upregulation of hepcidin both limiting iron absorption from the gut and preventing effective mobilization of iron stores for erythropoiesis. However, hepcidin-independent mechanisms of the anaemia of chronic disease exist and must be considered in assessing the underlying aetiology of otherwise unexplained anaemia. Interactions between the anaemia of chronic disease and other forms of anaemia are common. The management of the anaemia of inflammation rests in large part on the treatment of the underlying disease(s) where possible. In cases where anaemia-specific treatment is required, iron supplementation—particularly intravenous iron—may have a role. There is limited evidence for the use of erythropoiesis-stimulating agents in certain circumstances.

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