Show Summary Details
Page of

Anaemia of inflammation 

Anaemia of inflammation
Chapter:
Anaemia of inflammation
Author(s):

Sant-Rayn Pasricha

, and Hal Drakesmith

DOI:
10.1093/med/9780198746690.003.0535
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 February 2021

The anaemia of inflammation is one of the commonest causes of anaemia, particularly in the elderly and in those with extensive comorbidities. Dysregulation of the hepcidin axis is central to its pathophysiology, with upregulation of hepcidin both limiting iron absorption from the gut and preventing effective mobilization of iron stores for erythropoiesis. However, hepcidin-independent mechanisms of the anaemia of chronic disease exist and must be considered in assessing the underlying aetiology of otherwise unexplained anaemia. Interactions between the anaemia of chronic disease and other forms of anaemia are common. The management of the anaemia of inflammation rests in large part on the treatment of the underlying disease(s) where possible. In cases where anaemia-specific treatment is required, iron supplementation—particularly intravenous iron—may have a role. There is limited evidence for the use of erythropoiesis-stimulating agents in certain circumstances.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.