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The kidney in sarcoidosis 

The kidney in sarcoidosis
Chapter:
The kidney in sarcoidosis
Author(s):

Ingeborg Hilderson

, and Jan Donck

DOI:
10.1093/med/9780198746690.003.0494
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date: 07 March 2021

Sarcoidosis is associated with a broad spectrum of renal manifestations, but clinically important disease occurs in few patients. The most common cause of renal dysfunction is abnormal calcium metabolism: untreated chronic hypercalcaemia and hypercalciuria causes progressive tubulointerstitial inflammation with associated calcium deposits, leading to nephrocalcinosis, which is the leading cause of chronic kidney disease. Interstitial granulomatous nephritis is the most typical histological finding, but development of renal insufficiency is unusual. A range of glomerulopathies can be associated with sarcoidosis. When treatment is required, steroids are the first line, with various steroid-sparing agents used in cases that are refractory.

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