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Proliferative glomerulonephritis 

Proliferative glomerulonephritis
Chapter:
Proliferative glomerulonephritis
Author(s):

Alan D. Salama

, and Mark A. Little

DOI:
10.1093/med/9780198746690.003.0486
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date: 26 February 2021

Proliferative glomerulonephritis describes the finding of increased cellularity of the glomerulus, which may be due to proliferation of intrinsic glomerular cells, infiltration of leucocytes, or both. This principally occurs in the context of glomerular deposition of immunoglobulins, immune complexes, or complement components. Different subtypes are described based on histological features: proliferation of mesangial cells, endocapillary proliferation, diffuse proliferation, or extracapillary proliferation (also termed crescentic glomerulonephritis). Patients will typically have haematuria, and this may be associated with proteinuria and/or impairment of excretory renal function and/or hypertension. The best characterized proliferative glomerulonephritis is poststreptococcal glomerulonephritis. This most commonly affects children, who present with nephritis about 2 weeks after pharyngitis or skin infection caused by streptococci of Lancefield group A. Treatment is directed at eradicating the infection with an appropriate antimicrobial and providing symptomatic relief. Recovery is the rule, although haematuria and proteinuria may persist.

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