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Thin membrane nephropathy 

Thin membrane nephropathy
Chapter:
Thin membrane nephropathy
Author(s):

Peter Topham

, and John Feehally

DOI:
10.1093/med/9780198746690.003.0483
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date: 27 February 2021

Thin membrane nephropathy is a common autosomal dominant glomerular disorder that results in persistent nonvisible haematuria and is pathologically characterized by the presence of diffuse and uniform thinning of the glomerular basement membrane. Recent genetic studies have identified mutations in the COL4A3 and COL4A4 genes in 40% of affected families. There is no specific treatment. Prognosis is excellent for most people, but a few cases with progressive renal impairment have been described.

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