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Crystal-related arthropathies 

Crystal-related arthropathies
Crystal-related arthropathies

Edward Roddy

, and Michael Doherty

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date: 25 February 2021

Many crystals have been associated with arthropathies or periarticular syndromes: only monosodium urate (gout), calcium pyrophosphate (acute calcium pyrophosphate crystal arthritis, chondrocalcinosis), and basic calcium phosphates (mainly hydroxyapatite) are common. Crystals implicated in joint disease are stable, hard particles that exert biological effects via surface-active (activation of humoral and cell-derived mediators, interaction with cell membranes) and mechanical properties. In general, smaller particle size, marked surface irregularity, and high negative surface charge correlate with inflammatory potential. A ‘crystal deposition disease’ is defined as a pathological condition associated with mineral deposits that contribute directly to the pathology. This is probably the situation for all manifestations of gout, for acute syndromes associated with calcium pyrophosphate, and for acute apatite periarthritis.

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