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Persistent problems and recovery after critical illness 

Persistent problems and recovery after critical illness
Persistent problems and recovery after critical illness

Mark E. Mikkelsen

, and Theodore J. Iwashyna

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date: 02 March 2021

Post-intensive care syndrome is defined as new or worsening impairment in cognition, mental health, or physical function that persists after a critical illness. The complexities of post-intensive care syndrome come from the interactions of the patient’s premorbid mental health and physical function, the acute physiologic derangements and acute organ injury of the critical illness, and the side effects of procedures, treatments, and potential complications incurred during the critical illness. Problems are better described as challenging syndromes rather than specific actionable diagnoses, with the four major functional problems for patients being weakness, cognitive impairment, psychological problems, and new or worsened organ dysfunction. The sequelae of critical illness often extend beyond patients and impact the families of critically ill patients.

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