Show Summary Details
Page of

The evolution of therapeutic antibodies 

The evolution of therapeutic antibodies
Chapter:
The evolution of therapeutic antibodies
Author(s):

Herman Waldmann

, and Greg Winter

DOI:
10.1093/med/9780198746690.003.0036
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 07 March 2021

The development of rodent monoclonal antibodies opened the door to the creation of antibodies specific to soluble and cell-surface antigens. ‘Humanized’ therapeutic antibodies have emerged as major blockbuster drugs for the treatment of cancer, immune, and inflammatory disorders—the so-called biologics. Much of this revolution was spearheaded in Cambridge, England, initiated by the research of Cesar Milstein and George Köhler at the MRC Laboratory of Molecular Biology and who, with N.K. Jerne, shared the 1984 Nobel Prize for Medicine or Physiology. As related in this personal perspective, Cambridge scientists and clinicians took up the challenge to develop the original murine antibodies into powerful pharmaceuticals that can be administered repeatedly without the dire consequences of alloimmunization. In this short chapter, two scientists who made seminal contributions to this field and remain actively engaged in its development give a personal account of how these remarkable developments came about.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.