Show Summary Details
Page of

Liver and biliary diseases in infancy and childhood 

Liver and biliary diseases in infancy and childhood
Liver and biliary diseases in infancy and childhood

Richard J. Thompson

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 07 March 2021

Most liver diseases that occur in adults also occur in children, but some present almost exclusively in early childhood. Neonatal jaundice is common and usually short-lived. Onset before 24 h, or continuation beyond 2 weeks, strongly suggests an underlying pathology, when biliary atresia is the most common cause, with liver transplantation allowing some patients to survive to adolescence and adulthood. Some genetic causes of cholestasis (e.g. MDR3 deficiency) can present in adults. A long list of metabolic disorders present with evidence of liver involvement, with later manifesting diseases including those with accumulation of material in the liver. Liver transplantation is an excellent treatment for many of these disorders, and a growing number of metabolic disorders that do not cause liver disease per se are now being successfully managed through liver replacement, with patients surviving into adult life.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.