Show Summary Details
Page of



M.A. Shikanai-Yasuda

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 28 February 2021

Paracoccidioidomycosis is a systemic endemic mycosis caused by dimorphic fungus found in soil and in a variety of animals, and transmitted to humans by inhalation. It is restricted geographically to Central and South America, where it is the most common endemic chronic human mycosis, acquired in rural and periurban areas. In its chronic form is is more frequqnt in men than women (10:1) and in the acute form, it is equally distributed among boys and girls (children, adolescents and young adults) areas. It involves the lung and mucous membranes, adrenal, gastrointestinal, central nervous system and other organs in thechronic form and the phagocytic mononuclear system in the acute form. Diagnosis is made by direct microscopy or culture from sputum, plus histopathology.and/or serology, which is useful for therapeutic control. Treatment is required for long courses of oral drugs (itraconazole or sulfamethoxazole– trimethoprim) for non severe cases) or intravenous amphotericin B or other amphotericin formulations in severe cases followed by oral drugs.for severe cases. Sequels are represented by microstomia, laryngeal/tracheal/bronchial stenosis, pulmonary emphysema/fibrosis, respiratory insufficiency, and cor pulmonale.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.