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Contents
- Front Matter
- Section 1 Patients and their treatmentEdited by Section editors: John D. Firth, Christopher P. Conlon, and Timothy M. Cox
- 1.1 On being a patientChristopher Booth
- 1.2 A young person’s experience of chronic diseaseAnonymous
- 1.3 What patients wish you understoodRosamund Snow
- 1.4 Why do patients attend and what do they want from the consultation?Des Spence
- 1.5 Medical ethicsMike Parker, Mehrunisha Suleman, and Tony Hope
- 1.6 Clinical decision-makingTimothy E.A. Peto and Philippa Peto
- Section 2 Background to medicineEdited by Section editors: John D. Firth, Christopher P. Conlon, and Timothy M. Cox
- 2.1 Science in medicine: When, how, and whatWilliam F. Bynum
- 2.2 Evolution: Medicine’s most basic science
Randolph M. Nesse and Richard Dawkins - 2.3 The Global Burden of Disease: Measuring the health of populationsTheo Vos, Alan Lopez, and Christopher Murray
- 2.4 Large-scale randomized evidence: Trials and meta-analyses of trialsColin Baigent, Richard Peto, Richard Gray, Natalie Staplin, Sarah Parish, and Rory Collins
- 2.5 BioinformaticsAfzal Chaudhry
- 2.6 Principles of clinical pharmacology and drug therapyKevin O’Shaughnessy
- 2.7 Biological therapies for immune, inflammatory, and allergic diseasesJohn D. Isaacs and Nishanthi Thalayasingam
- 2.8 Traditional medicine exemplified by traditional Chinese medicine Fulong Liao, Tingliang Jiang, and Youyou Tu
- 2.9 Engaging patients in therapeutic developmentEmil Kakkis and Max Bronstein
- 2.10 Medicine quality, physicians, and patientsPaul N. Newton
- 2.11 Preventive medicineDavid Mant
- 2.12 Medical screeningNicholas Wald and Malcolm Law
- 2.13 Health promotionEvelyne de Leeuw
- 2.14 Deprivation and healthHarry Burns
- 2.15 How much should rich countries’ governments spend on healthcare?Allyson M. Pollock and David Price
- 2.16 Financing healthcare in low-income developing countries: A challenge for equity in healthLuis G. Sambo, Jorge Simões, and Maria do Rosario O. Martins
- 2.17 Research in the developed world (a view from the Wellcome Trust)Jeremy Farrar
- 2.18 Fostering medical and health research in resource-constrained countriesMalegapuru W. Makgoba and Stephen M. Tollman
- 2.19 Regulation versus innovation in medicineMichael Rawlins
- 2.20 Human disastersAmartya Sen
- 2.21 Humanitarian medicineAmy S. Kravitz
- 2.22 Complementary and alternative medicineEdzard Ernst
- Section 3 Cell biologyEdited by Section editors: John D. Firth, Christopher P. Conlon, and Timothy M. Cox
- 3.1 The cellGeorge Banting and J. Paul Luzio
- 3.2 The genomic basis of medicinePaweł Stankiewicz and James R. Lupski
- 3.3 CytokinesIain B. McInnes
- 3.4 Ion channels and diseaseFrances Ashcroft and Paolo Tammaro
- 3.5 Intracellular signallingR. Andres Floto
- 3.6 Apoptosis in health and diseaseMark J. Arends and Christopher D. Gregory
- 3.7 Stem cells and regenerative medicineAlexis J. Joannides, Bhuvaneish T. Selvaraj, and Siddharthan Chandran
- 3.8 The evolution of therapeutic antibodiesHerman Waldmann and Greg Winter
- 3.9 Circulating DNA for molecular diagnosticsY.M. Dennis Lo and Rossa W.K. Chiu
- Section 4 Immunological mechanismsEdited by Section editors: John D. Firth, Christopher P. Conlon, and Timothy M. Cox
- 4.1 The innate immune systemPaul Bowness
- 4.2 The complement systemMarina Botto and Matthew C. Pickering
- 4.3 Adaptive immunityPaul Klenerman and Constantino López-Macias
- 4.4 ImmunodeficiencySophie Hambleton, Sara Marshall, and Dinakantha S. Kumararatne
- 4.5 AllergyPamela Ewan
- 4.6 AutoimmunityAntony Rosen
- 4.7 Principles of transplantation immunologyElizabeth Wallin and Kathryn J. Wood
- Section 5 Principles of clinical oncologyEdited by Section editors: John D. Firth, Christopher P. Conlon, and Timothy M. Cox
- 5.1 Epidemiology of cancerAnthony Swerdlow and Richard Peto
- 5.2 The nature and development of cancer: Cancer mutations and their implicationsJames D. Brenton and Tim Eisen
- 5.3 The genetics of inherited cancersRosalind A. Eeles
- 5.4 Cancer immunity and immunotherapyCharles G. Drake
- 5.5 Clinical features and managementTim Eisen and Martin Gore
- 5.6 Systemic treatment and radiotherapyRajesh Jena and Peter Harper
- 5.7 Medical management of breast cancerTim Crook, Su Li, and Peter Harper
- Section 6 Old age medicineEdited by Section editor: Finbarr C. Martin
- 6.1 Ageing and clinical medicineClaire Steves and Neil Pendleton
- 6.2 Frailty and sarcopeniaAndrew Clegg and Harnish Patel
- 6.3 Optimizing well-being into old ageSteve Iliffe
- 6.4 Older people and urgent careSimon Conroy and Jay Banerjee
- 6.5 Older people in hospitalGraham Ellis, Alasdair MacLullich, and Rowan Harwood
- 6.6 Supporting older peoples’ care in surgical and oncological servicesJugdeep Dhesi and Judith Partridge
- 6.7 Drugs and prescribing in the older patientMiles Witham, Jacob George, and Denis O’Mahony
- 6.8 Falls, faints, and fragility fracturesFiona Kearney and Tahir Masud
- 6.9 Bladder and bowelsSusie Orme and Danielle Harari
- 6.10 Neurodegenerative disorders in older peopleJohn Hindle
- 6.11 Promotion of dignity in the life and death of older patientsEileen Burns and Claire Scampion
- Section 7 Pain and palliative careEdited by Section editor: Bee Wee
- 7.1 Introduction to palliative careSusan Salt
- 7.2 Pain managementMarie Fallon
- 7.3 Symptoms other than painRegina McQuillan
- 7.4 Care of the dying personSuzanne Kite and Adam Hurlow
- Section 8 Infectious diseasesEdited by Section editor: Christopher P. Conlon
- 8.1 Pathogenic microorganisms and the host
- 8.1.1 Biology of pathogenic microorganismsDuncan J. Maskell and James L.N. Wood
- 8.1.2 Clinical features and general management of patients with severe infectionsPeter Watkinson and Duncan Young
- 8.2 The patient with suspected infection
- 8.2.1 Clinical approachChristopher J. Ellis
- 8.2.2 Fever of unknown originSteven Vanderschueren
- 8.2.3 Nosocomial infectionsIan C.J.W. Bowler and Matthew Scarborough
- 8.2.4 Infection in the immunocompromised hostJon Cohen and Elham Khatamzas
- 8.2.5 Antimicrobial chemotherapyMaha Albur, Alasdair MacGowan, and Roger G. Finch
- 8.3 ImmunizationDavid Goldblatt and Mary Ramsay
- 8.4 Travel and expedition medicineSusanna Dunachie and Christopher P. Conlon
- 8.5 Viruses
- 8.5.1 Respiratory tract viruses Malik Peiris
- 8.5.2 Herpesviruses (excluding Epstein–Barr virus)J.G.P. Sissons
- 8.5.3 Epstein–Barr virusAlan B. Rickinson and M.A. Epstein
- 8.5.4 PoxvirusesGeoffrey L. Smith
- 8.5.5 Mumps: Epidemic parotitisB.K. Rima
- 8.5.6 MeaslesHilton C. Whittle and Peter Aaby
- 8.5.7 Nipah and Hendra virus encephalitidesC.T. Tan
- 8.5.8 Enterovirus infectionsPhilip Minor and Ulrich Desselberger
- 8.5.9 Virus infections causing diarrhoea and vomitingPhilip R. Dormitzer and Ulrich Desselberger
- 8.5.10 Rhabdoviruses: Rabies and rabies-related lyssavirusesMary J. Warrell and David A. Warrell
- 8.5.11 Colorado tick fever and other arthropod-borne reovirusesMary J. Warrell and David A. Warrell
- 8.5.12 AlphavirusesAnn M. Powers, E.E. Ooi, L.R. Petersen, and D.J. Gubler
- 8.5.13 RubellaPat Tookey and J.M. Best
- 8.5.14 Flaviviruses excluding dengueShannan Lee Rossi and Nikos Vasilakis
- 8.5.15 DengueBridget Wills and Yee-Sin Leo
- 8.5.16 BunyaviridaeJames W. Le Duc and D.A. Bente
- 8.5.17 ArenavirusesJan H. ter Meulen
- 8.5.18 FilovirusesJan H. ter Meulen
- 8.5.19 Papillomaviruses and polyomavirusesRaphael P. Viscidi, Chen Sabrina Tan, and Carole Fakhry
- 8.5.20 Parvovirus B19Kevin E. Brown
- 8.5.21 Hepatitis viruses (excluding hepatitis C virus)Matthew Cramp, Ashwin Dhanda, and Nikolai V. Naoumov
- 8.5.22 Hepatitis C virusPaul Klenerman, Katie J.M. Jeffery, Ellie J. Barnes, and Jane Collier
- 8.5.23 HIV/AIDSSarah Fidler, Timothy E.A. Peto, Philip Goulder, and Christopher P. Conlon
- 8.5.24 HIV in low- and middle-income countriesAlison D. Grant and Kevin M. De Cock
- 8.5.25 HTLV-1, HTLV-2, and associated diseasesKristien Verdonck and Eduardo Gotuzzo
- 8.5.26 Viruses and cancerRobin A. Weiss
- 8.5.27 Orf and Milker’s noduleEmma Aarons and David A. Warrell
- 8.5.28 Molluscum contagiosumDavid A. Warrell and Christopher P. Conlon
- 8.5.29 Newly discovered viruses Susannah J.A. Froude and Harriet C. Hughes
- 8.6 Bacteria
- 8.6.1 DiphtheriaDelia B. Bethell and Tran Tinh Hien
- 8.6.2 Streptococci and enterococci
Dennis L. Stevens and Sarah Hobdey - 8.6.3 Pneumococcal infectionsAnthony Scott
- 8.6.4 StaphylococciKyle J. Popovich, Robert A. Weinstein, and Bala Hota
- 8.6.5 Meningococcal infectionsPetter Brandtzaeg
- 8.6.6 Neisseria gonorrhoeaeJackie Sherrard and Magnus Unemo
- 8.6.7 Enterobacteria and bacterial food poisoningHugh Pennington
- 8.6.8 Pseudomonas aeruginosaG.C.K.W. Koh and Sharon J. Peacock
- 8.6.9 Typhoid and paratyphoid fevers
Christopher M. Parry and Buddha Basnyat - 8.6.10 Intracellular klebsiella infections (donovanosis and rhinoscleroma)John Richens and Nicole Stoesser
- 8.6.11 Anaerobic bacteriaAnilrudh A. Venugopal and David W. Hecht
- 8.6.12 CholeraAldo A.M. Lima and Richard L. Guerrant
- 8.6.13 Haemophilus influenzae
Esther Robinson - 8.6.14 Haemophilus ducreyi and chancroidNigel O’Farrell
- 8.6.15 Bordetella infectionCameron C. Grant
- 8.6.16 Melioidosis and glandersSharon J. Peacock
- 8.6.17 Plague: Yersinia pestis
Michael Prentice - 8.6.18 Other Yersinia infections: YersiniosisMichael Prentice
- 8.6.19 PasteurellaMarina S. Morgan
- 8.6.20 Francisella tularensis infectionPetra C.F. Oyston
- 8.6.21 AnthraxArthur E. Brown
- 8.6.22 BrucellosisJuan D. Colmenero and Pilar Morata
- 8.6.23 TetanusC. Louise Thwaites and Lam Minh Yen
- 8.6.24 Clostridium difficileDavid W. Eyre and Mark H. Wilcox
- 8.6.25 Botulism, gas gangrene, and clostridial gastrointestinal infections
Dennis L. Stevens, Michael J. Aldape, and Amy E. Bryant - 8.6.26 TuberculosisRichard E. Chaisson and Jean B. Nachega
- 8.6.27 Disease caused by environmental mycobacteriaJakko van Ingen
- 8.6.28 Leprosy (Hansen’s disease)Diana N.J. Lockwood
- 8.6.29 Buruli ulcer: Mycobacterium ulcerans infectionBouke de Jong, Françoise Portaels, and Wayne M. Meyers
- 8.6.30 ActinomycosesKlaus P. Schaal
- 8.6.31 NocardiosisRoderick J. Hay
- 8.6.32 Rat bite fevers (Streptobacillus moniliformis and Spirillum minus infection)Andrew F. Woodhouse
- 8.6.33 Lyme borreliosisGary P. Wormser, John Nowakowski, and Robert B. Nadelman
- 8.6.34 Relapsing feversDavid A. Warrell
- 8.6.35 LeptospirosisNicholas P.J. Day
- 8.6.36 Nonvenereal endemic treponematoses: Yaws, endemic syphilis (bejel), and pintaMichael Marks, Oriol Mitjà, and David Mabey
- 8.6.37 SyphilisPhillip Read and Basil Donovan
- 8.6.38 ListeriosisHerbert Hof
- 8.6.39 Legionellosis and legionnaires’ diseaseDiego Viasus and Jordi Carratalà
- 8.6.40 RickettsiosesKarolina Griffiths, Carole Eldin, Didier Raoult, and Philippe Parola
- 8.6.41 Scrub typhusDaniel H. Paris and Nicholas P.J. Day
- 8.6.42 Coxiella burnetii infections (Q fever)Thomas J. Marrie
- 8.6.43 Bartonellas excluding B. bacilliformisBruno B. Chomel, Henri-Jean Boulouis, Matthew J. Stuckey, and Jean-Marc Rolain
- 8.6.44 Bartonella bacilliformis infectionA. Llanos-Cuentas and C. Maguiña-Vargas
- 8.6.45 Chlamydial infectionsPatrick Horner, David Mabey, David Taylor-Robinson, and Magnus Unemo
- 8.6.46 MycoplasmasJørgen Skov Jensen and David Taylor-Robinson
- 8.6.47 A checklist of bacteria associated with infection in humansJohn Paul
- 8.7 Fungi (mycoses)
- 8.7.1 Fungal infectionsRoderick J. Hay
- 8.7.2 CryptococcosisWilliam G. Powderly, J. William Campbell, and Larry J. Shapiro
- 8.7.3 CoccidioidomycosisGregory M. Anstead
- 8.7.4 ParacoccidioidomycosisM.A. Shikanai-Yasuda
- 8.7.5 Pneumocystis jiroveciiRobert F. Miller and Christopher P. Eades
- 8.7.6 Talaromyces (Penicillium) marneffei infectionRomanee Chaiwarith, Khuanchai Supparatpinyo, and Thira Sirisanthana
- 8.7.7 MicrosporidiosisLouis M. Weiss
- 8.8 Protozoa
- 8.8.1 Amoebic infectionsRichard Knight
- 8.8.2 MalariaNicholas J. White and Arjen M. Dondorp
- 8.8.3 BabesiosisPhilippe Brasseur
- 8.8.4 ToxoplasmosisOliver Liesenfeld and Eskild Petersen
- 8.8.5 Cryptosporidium and cryptosporidiosis
Simone M. Cacciò - 8.8.6 Cyclospora and cyclosporiasisPaul Kelly and Ralph Lainson
- 8.8.7 CystoisosporiasisLouis M. Weiss
- 8.8.8 Sarcocystosis (sarcosporidiosis)
John E. Cooper - 8.8.9 Giardiasis and balantidiasisLars Eckmann and Martin F. Heyworth
- 8.8.10 Blastocystis infectionRichard Knight
- 8.8.11 Human African trypanosomiasis
Reto Brun and Johannes Blum - 8.8.12 Chagas diseaseMichael A. Miles
- 8.8.13 LeishmaniasisAntony D.M. Bryceson and Diana N.J. Lockwood
- 8.8.14 Trichomoniasis
Jane Schwebke
- 8.9 Nematodes (roundworms)
- 8.9.1 Cutaneous filariasisGilbert Burnham
- 8.9.2 Lymphatic filariasisRichard Knight
- 8.9.3 Guinea worm disease (dracunculiasis)Richard Knight
- 8.9.4 Strongyloidiasis, hookworm, and other gut strongyloid nematodesMichael Brown
- 8.9.5 Gut and tissue nematode infections acquired by ingestionPeter L. Chiodini
- 8.9.6 AngiostrongyliasisRichard Knight
- 8.10 Cestodes (tapeworms)
- 8.10.1 Cestodes (tapeworms)Richard Knight
- 8.10.2 Cystic hydatid disease (Echinococcus granulosus)Pedro L. Moro, Hector H. Garcia, and Armando E. Gonzalez
- 8.10.3 CysticercosisHector H. Garcia and Robert H. Gilman
- 8.11 Trematodes (flukes)
- 8.11.1 SchistosomiasisDavid Dunne and Birgitte Vennervald
- 8.11.2 Liver fluke infections
Ross H. Andrews, Narong Khuntikeo, Paiboon Sithithaworn, and Trevor N. Petney - 8.11.3 Lung flukes (paragonimiasis)Udomsak Silachamroon and Sirivan Vanijanonta
- 8.11.4 Intestinal trematode infectionsAlastair McGregor
- 8.12 Nonvenomous arthropodsJohn Paul
- 8.13 Pentastomiasis (porocephalosis, linguatulosis/linguatuliasis, or tongue worm infection)David A. Warrell
- 8.1 Pathogenic microorganisms and the host
- Section 9 Sexually transmitted diseasesEdited by Section editor: Jackie Sherrard
- 9.1 Epidemiology of sexually transmitted infectionsDavid Mabey and Anita Vas-Falcao
- 9.2 Sexual behaviourCatherine H. Mercer and Anne M. Johnson
- 9.3 Sexual history and examinationGary Brook, Jackie Sherrard, and Graz A. Luzzi
- 9.4 Vaginal dischargePaul Nyirjesy
- 9.5 UrethritisPatrick Horner
- 9.6 Genital ulcerationPatrick French and Raj Patel
- 9.7 Anogenital lumps and bumpsHenry J.C. de Vries and Charles J.N. Lacey
- 9.8 Pelvic inflammatory diseaseJonathan D.C. Ross
- 9.9 Principles of contraceptionZara Haider
- Section 10 Environmental medicine, occupational medicine, and poisoningEdited by Section editor: Jon G. Ayres
- 10.1 Environmental medicine, occupational medicine, and poisoning—IntroductionJon G. Ayres
- 10.2 Occupational health
- 10.2.1 Occupational and environmental healthRaymond Agius and Debasish Sen
- 10.2.2 Occupational safetyLawrence Waterman
- 10.2.3 Aviation medicineMichael Bagshaw
- 10.2.4 Diving medicineDavid M. Denison and Mark A. Glover
- 10.2.5 NoiseDavid Koh and Tar-Ching Aw
- 10.2.6 VibrationTar-Ching Aw
- 10.3 Environment and health
- 10.3.1 Air pollution and healthOm P. Kurmi, Kin Bong Hubert Lam, and Jon G. Ayres
- 10.3.2 HeatMichael A. Stroud
- 10.3.3 ColdMichael A. Stroud
- 10.3.4 DrowningPeter J. Fenner
- 10.3.5 Lightning and electrical injuriesChris Andrews
- 10.3.6 Diseases of high terrestrial altitudesTyler Albert, Erik R. Swenson, Andrew J. Pollard, Buddha Basnyat, and David R. Murdoch
- 10.3.7 RadiationJill Meara
- 10.3.8 Disasters: Earthquakes, hurricanes, floods, and volcanic eruptionsPeter J. Baxter
- 10.3.9 BioterrorismManfred S. Green
- 10.4 Poisoning
- 10.4.1 Poisoning by drugs and chemicalsJohn A. Vale, Sally M. Bradberry, and D. Nicholas Bateman
- 10.4.2 Injuries, envenoming, poisoning, and allergic reactions caused by animalsDavid A. Warrell
- 10.4.3 Poisonous fungiHans Persson and David A. Warrell
- 10.4.4 Poisonous plantsMichael Eddleston and Hans Persson
- 10.5 Podoconiosis (nonfilarial elephantiasis)Gail Davey
- Section 11 NutritionEdited by Section editor: Katherine Younger
- 11.1 Nutrition: Macronutrient metabolismKeith N. Frayn and Rhys D. Evans
- 11.2 VitaminsTom R. Hill and David A. Bender
- 11.3 Minerals and trace elementsKatherine Younger
- 11.4 Severe malnutritionAlan A. Jackson
- 11.5 Diseases of affluent societies and the need for dietary changeJ.I. Mann and A.S. Truswell
- 11.6 ObesityI. Sadaf Farooqi
- 11.7 Artificial nutrition supportJeremy Woodward
- Section 12 Metabolic disordersEdited by Section editor: Timothy M. Cox
- 12.1 The inborn errors of metabolism: General aspectsTimothy M. Cox and Richard W.E. Watts
- 12.2 Protein-dependent inborn errors of metabolismGeorg F. Hoffmann and Stefan Kölker
- 12.3 Disorders of carbohydrate metabolism
- 12.3.1 Glycogen storage diseasesRobin H. Lachmann and Timothy M. Cox
- 12.3.2 Inborn errors of fructose metabolismTimothy M. Cox
- 12.3.3 Disorders of galactose, pentose, and pyruvate metabolismTimothy M. Cox
- 12.4 Disorders of purine and pyrimidine metabolismAnthony M. Marinaki, Lynette D. Fairbanks, and Richard W.E. Watts
- 12.5 The porphyriasTimothy M. Cox
- 12.6 Lipid disordersJaimini Cegla and James Scott
- 12.7 Trace metal disorders
- 12.7.1 Hereditary haemochromatosisWilliam J.H. Griffiths and Timothy M. Cox
- 12.7.2 Inherited diseases of copper metabolism: Wilson’s disease and Menkes’ diseaseMichael L. Schilsky and Pramod K. Mistry
- 12.8 Lysosomal diseasePatrick B. Deegan and Timothy M. Cox
- 12.9 Disorders of peroxisomal metabolism in adultsAnthony S. Wierzbicki
- 12.10 Hereditary disorders of oxalate metabolism: The primary hyperoxaluriasSonia Fargue, Dawn S. Milliner, and Christopher J. Danpure
- 12.11 A physiological approach to acid–base disorders: The roles of ion transport and body fluid compartments Julian Seifter
- 12.12 The acute phase response, hereditary periodic fever syndromes, and amyloidosis
- 12.12.1 The acute phase response and C-reactive proteinMark B. Pepys
- 12.12.2 Hereditary periodic fever syndromesHelen J. Lachmann, Stefan Berg, and Philip N. Hawkins
- 12.12.3 AmyloidosisMark B. Pepys and Philip N. Hawkins
- 12.13 α1-Antitrypsin deficiency and the serpinopathiesDavid A. Lomas
- Section 13 Endocrine disordersEdited by Section editor: Mark Gurnell
- 13.1 Principles of hormone actionRob Fowkes, V. Krishna Chatterjee, and Mark Gurnell
- 13.2 Pituitary disorders
- 13.2.1 Disorders of the anterior pituitary glandNiki Karavitaki and John A.H. Wass
- 13.2.2 Disorders of the posterior pituitary glandNiki Karavitaki, Shahzada K. Ahmed, and John A.H. Wass
- 13.3 Thyroid disorders
- 13.3.1 The thyroid gland and disorders of thyroid functionAnthony P. Weetman and Kristien Boelaert
- 13.3.2 Thyroid cancerKristien Boelaert and Anthony P. Weetman
- 13.4 Parathyroid disorders and diseases altering calcium metabolismR.V. Thakker
- 13.5 Adrenal disorders
- 13.5.1 Disorders of the adrenal cortex
Mark Sherlock and Mark Gurnell - 13.5.2 Congenital adrenal hyperplasiaNils P. Krone and Ieuan A. Hughes
- 13.5.1 Disorders of the adrenal cortex
- 13.6 Reproductive disorders
- 13.6.1 Ovarian disordersStephen Franks, Kate Hardy, and Lisa J. Webber
- 13.6.2 Disorders of male reproduction and male hypogonadismP.-M.G. Bouloux
- 13.6.3 Benign breast diseaseGael M. MacLean
- 13.6.4 Sexual dysfunctionIan Eardley
- 13.7 Disorders of growth and development
- 13.7.1 Normal growth and its disordersGary Butler
- 13.7.2 Normal puberty and its disordersFiona Ryan and Sejal Patel
- 13.7.3 Normal and abnormal sexual differentiationS. Faisal Ahmed and Angela K. Lucas-Herald
- 13.8 Pancreatic endocrine disorders and multiple endocrine neoplasiaB. Khoo, T.M. Tan, and S.R. Bloom
- 13.9 Diabetes and hypoglycaemia
- 13.9.1 DiabetesColin Dayan and Julia Platts
- 13.9.2 HypoglycaemiaMark Evans and Ben Challis
- 13.10 Hormonal manifestations of nonendocrine diseaseThomas M. Barber and John A.H. Wass
- 13.11 The pineal gland and melatoninJ. Arendt and Timothy M. Cox
- Section 14 Medical disorders in pregnancyEdited by Section editor: Catherine Nelson-Piercy
- 14.1 Physiological changes of normal pregnancyDavid J. Williams
- 14.2 Nutrition in pregnancyDavid J. Williams
- 14.3 Medical management of normal pregnancyDavid J. Williams
- 14.4 Hypertension in pregnancyFergus McCarthy
- 14.5 Renal disease in pregnancyKate Wiles
- 14.6 Heart disease in pregnancyCatherine E.G. Head
- 14.7 Thrombosis in pregnancyPeter K. MacCallum and Louise Bowles
- 14.8 Chest diseases in pregnancyMeredith Pugh and Tina Hartert
- 14.9 Liver and gastrointestinal diseases of pregnancyMichael Heneghan and Catherine Williamson
- 14.10 Diabetes in pregnancyBryony Jones and Anne Dornhorst
- 14.11 Endocrine disease in pregnancyDavid Carty
- 14.12 Neurological conditions in pregnancyPooja Dassan
- 14.13 The skin in pregnancyGudula Kirtschig and Fenella Wojnarowska
- 14.14 Autoimmune rheumatic disorders and vasculitis in pregnancyMay Ching Soh and Catherine Nelson-Piercy
- 14.15 Maternal infection in pregnancyRosie Burton
- 14.16 Fetal effects of maternal infectionLawrence Impey
- 14.17 Blood disorders in pregnancyDavid J. Perry and Katharine Lowndes
- 14.18 Malignant disease in pregnancyRobin A.F. Crawford
- 14.19 Maternal critical careRupert Gauntlett
- 14.20 Prescribing in pregnancyLucy MacKillop and Charlotte Frise
- 14.21 Contraception for women with medical diseasesAarthi R. Mohan
- Section 15 Gastroenterological disordersEdited by Section editor: Jack Satsangi
- 15.1 Structure and function of the gastrointestinal tractMichael E.B. FitzPatrick and Satish Keshav
- 15.2 Symptoms of gastrointestinal diseaseJeremy Woodward
- 15.3 Methods for investigation of gastroenterological disease
- 15.3.1 Colonoscopy and flexible sigmoidoscopyJames E. East and Brian P. Saunders
- 15.3.2 Upper gastrointestinal endoscopyJames E. East and George J. Webster
- 15.3.3 Radiology of the gastrointestinal tractFiachra Moloney and Michael Maher
- 15.3.4 Investigation of gastrointestinal functionJervoise Andreyev
- 15.4 Common acute abdominal presentations
- 15.4.1 The acute abdomenSimon J.A. Buczacki and R. Justin Davies
- 15.4.2 Gastrointestinal bleedingVanessa Brown and T.A. Rockall
- 15.5 Immune disorders of the gastrointestinal tractJoya Bhattacharyya and Arthur Kaser
- 15.6 The mouth and salivary glandsJohn Gibson and Douglas Robertson
- 15.7 Diseases of the oesophagusRebecca C. Fitzgerald and Massimiliano di Pietro
- 15.8 Peptic ulcer diseaseJoseph Sung
- 15.9 Hormones and the gastrointestinal tract
- 15.9.1 Hormones and the gastrointestinal tractRebecca Scott, T.M. Tan, and S.R. Bloom
- 15.9.2 Carcinoid syndromeB. Khoo, T.M. Tan, and S.R. Bloom
- 15.10 Malabsorption
- 15.10.1 Differential diagnosis and investigation of malabsorptionAlastair Forbes and Victoria Mulcahy
- 15.10.2 Bacterial overgrowth of the small intestineStephen J. Middleton and Raymond J. Playford
- 15.10.3 Coeliac diseasePeter D. Mooney and David S. Sanders
- 15.10.4 Gastrointestinal lymphomasKikkeri N. Naresh
- 15.10.5 Disaccharidase deficiencyTimothy M. Cox
- 15.10.6 Whipple’s diseaseFlorence Fenollar and Didier Raoult
- 15.10.7 Effects of massive bowel resectionStephen J. Middleton, Simon M. Gabe, and Raymond J. Playford
- 15.10.8 Malabsorption syndromes in the tropicsVineet Ahuja and Govind K. Makharia
- 15.11 Crohn’s diseaseMiles Parkes and Tim Raine
- 15.12 Ulcerative colitis
Jeremy Sanderson and Peter Irving - 15.13 Irritable bowel syndromeAdam D. Farmer and Qasim Aziz
- 15.14 Colonic diverticular diseaseNicolas C. Buchs, Roel Hompes, Shazad Q. Ashraf, and Neil J.McC. Mortensen
- 15.15 Congenital abnormalities of the gastrointestinal tractHolm H. Uhlig
- 15.16 Cancers of the gastrointestinal tractPeter L. Labib, J.A. Bridgewater, and Stephen P. Pereira
- 15.17 Vascular disorders of the gastrointestinal tractRay Boyapati
- 15.18 Gastrointestinal infectionsSarah O’Brien
- 15.19 Miscellaneous disorders of the bowelAlexander Gimson
- 15.20 Structure and function of the liver, biliary tract, and pancreasWilliam Gelson and Alexander Gimson
- 15.21 Pathobiology of chronic liver diseaseWajahat Z. Mehal
- 15.22 Presentations and management of liver disease
- 15.22.1 Investigation and management of jaundiceJane Collier
- 15.22.2 Cirrhosis and ascites
Javier Fernández and Vicente Arroyo - 15.22.3 Portal hypertension and variceal bleedingMarcus Robertson and Peter Hayes
- 15.22.4 Hepatic encephalopathyPaul K. Middleton and Debbie L. Shawcross
- 15.22.5 Liver failureJane Macnaughtan and Rajiv Jalan
- 15.22.6 Liver transplantationJohn G. O’Grady
- 15.23 Hepatitis and autoimmune liver disease
- 15.23.1 Hepatitis A to EGraeme J.M. Alexander and Kate Nash
- 15.23.2 Autoimmune hepatitisG.J. Webb and Gideon M. Hirschfield
- 15.23.3 Primary biliary cholangitisJessica K. Dyson and David E.J. Jones
- 15.23.4 Primary sclerosing cholangitisKate D. Lynch and Roger W. Chapman
- 15.24 Other liver diseases
- 15.24.1 Alcoholic liver diseaseEwan Forrest
- 15.24.2 Nonalcoholic fatty liver diseaseQuentin M. Anstee and Christopher P. Day
- 15.24.3 Drug-induced liver diseaseGuruprasad P. Aithal
- 15.24.4 Vascular disorders of the liverAlexander Gimson
- 15.24.5 The liver in systemic diseaseJames Neuberger
- 15.24.6 Primary and secondary liver tumoursGraeme J.M. Alexander, David J. Lomas, William J.H. Griffiths, Simon M. Rushbrook, and Michael E.D. Allison
- 15.24.7 Liver and biliary diseases in infancy and childhoodRichard J. Thompson
- 15.25 Diseases of the gallbladder and biliary treeColin Johnson and Mark Wright
- 15.26 Diseases of the pancreas
- 15.26.1 Acute pancreatitisR. Carter, Euan J. Dickson, and C.J. McKay
- 15.26.2 Chronic pancreatitisMarco J. Bruno and Djuna L. Cahen
- 15.26.3 Tumours of the pancreasJames R.A. Skipworth and Stephen P. Pereira
- Section 16 Cardiovascular disordersEdited by Section editor: Jeremy Dwight
- 16.1 Structure and function
- 16.1.1 Blood vessels and the endotheliumKeith Channon and Patrick Vallance
- 16.1.2 Cardiac physiologyRhys D. Evans, Kenneth T. MacLeod, Steven B. Marston, Nicholas J. Severs, and Peter H. Sugden
- 16.2 Clinical presentation of heart disease
- 16.2.1 Chest pain, breathlessness, and fatigueJeremy Dwight
- 16.2.2 Syncope and palpitationK. Rajappan, A.C. Rankin, A.D. McGavigan, and S.M. Cobbe
- 16.3 Clinical investigation of cardiac disorders
- 16.3.1 ElectrocardiographyAndrew R. Houghton and David Gray
- 16.3.2 EchocardiographyJames D. Newton, Adrian P. Banning, and Andrew R.J. Mitchell
- 16.3.3 Cardiac investigations: Nuclear, MRI, and CTNikant Sabharwal, Andrew Kelion, Theodoros Karamitos, and Stefan Neubauer
- 16.3.4 Cardiac catheterization and angiographyEdward D. Folland
- 16.4 Cardiac arrhythmiasMatthew R. Ginks, D.A. Lane, A.D. McGavigan, and Gregory Y.H. Lip
- 16.5 Cardiac failure
- 16.5.1 Epidemiology and general pathophysiological classification of heart failureTheresa A. McDonagh and Kaushik Guha
- 16.5.2 Acute cardiac failure: Definitions, investigation, and managementAndrew L. Clark and John G.F. Cleland
- 16.5.3 Chronic heart failure: Definitions, investigation, and managementJohn G.F. Cleland and Andrew L. Clark
- 16.5.4 Cardiorenal syndromeDarren Green and Philip A. Kalra
- 16.5.5 Cardiac transplantation and mechanical circulatory supportJayan Parameshwar and Steven Tsui
- 16.6 Valvular heart diseaseMichael Henein
- 16.7 Diseases of heart muscle
- 16.7.1 MyocarditisJay W. Mason and Heinz-Peter Schultheiss
- 16.7.2 The cardiomyopathies: Hypertrophic, dilated, restrictive, and right ventricularOliver P. Guttmann and Perry Elliott
- 16.7.3 Specific heart muscle disordersOliver P. Guttmann and Perry Elliott
- 16.8 Pericardial diseaseMichael Henein
- 16.9 Cardiac involvement in infectious disease
- 16.9.1 Acute rheumatic feverJonathan R. Carapetis
- 16.9.2 EndocarditisJames L. Harrison, John L. Klein, William A. Littler, and Bernard D. Prendergast
- 16.9.3 Cardiac disease in HIV infectionPeter F. Currie
- 16.9.4 Cardiovascular syphilisKrishna Somers
- 16.10 Tumours of the heartThomas A. Traill
- 16.11 Cardiac involvement in genetic diseaseThomas A. Traill
- 16.12 Congenital heart disease in the adultS.A. Thorne
- 16.13 Coronary heart disease
- 16.13.1 Biology and pathology of atherosclerosisRobin P. Choudhury, Joshua T. Chai, and Edward A. Fisher
- 16.13.2 Coronary heart disease: Epidemiology and preventionGoodarz Danaei and Kazem Rahimi
- 16.13.3 Management of stable anginaAdam D. Timmis
- 16.13.4 Management of acute coronary syndromeRajesh K. Kharbanda and Keith A.A. Fox
- 16.13.5 Percutaneous interventional cardiac proceduresEdward D. Folland
- 16.13.6 Coronary artery bypass and valve surgeryRana Sayeed and David Taggart
- 16.14 Diseases of the arteries
- 16.14.1 Acute aortic syndromesJames D. Newton, Andrew R.J. Mitchell, and Adrian P. Banning
- 16.14.2 Peripheral arterial diseaseJanet Powell and Alun Davies
- 16.14.3 Cholesterol embolismChristopher Dudley
- 16.15 The pulmonary circulation
- 16.15.1 Structure and function of the pulmonary circulationNicholas W. Morrell
- 16.15.2 Pulmonary hypertensionNicholas W. Morrell
- 16.16 Venous thromboembolism
- 16.16.1 Deep venous thrombosis and pulmonary embolismPaul D. Stein, Fadi Matta, and John D. Firth
- 16.16.2 Therapeutic anticoagulationDavid Keeling
- 16.17 Hypertension
- 16.17.1 Essential hypertension: Definition, epidemiology, and pathophysiologyBryan Williams and John D. Firth
- 16.17.2 Essential hypertension: Diagnosis, assessment, and treatmentBryan Williams and John D. Firth
- 16.17.3 Secondary hypertensionMorris J. Brown and Fraz A. Mir
- 16.17.4 Mendelian disorders causing hypertensionNilesh J. Samani and Maciej Tomaszewski
- 16.17.5 Hypertensive urgencies and emergenciesGregory Y.H. Lip and Alena Shantsila
- 16.18 Chronic peripheral oedema and lymphoedemaPeter S. Mortimer
- 16.19 Idiopathic oedema of womenJohn D. Firth
- 16.1 Structure and function
- Section 17 Critical care medicineEdited by Section editor: Simon Finfer
- 17.1 The seriously ill or deteriorating patientCarole Foot and Liz Hickson
- 17.2 Cardiac arrestGavin D. Perkins, Jasmeet Soar, Jerry P. Nolan, and David A. Gabbott
- 17.3 AnaphylaxisAnthony F.T. Brown
- 17.4 Assessing and preparing patients with medical conditions for major surgeryTom Abbott and Rupert Pearse
- 17.5 Acute respiratory failureSusannah Leaver, Jeremy Cordingley, Simon Finney, and Mark Griffiths
- 17.6 Circulation and circulatory support in the critically illMichael R. Pinsky
- 17.7 Management of raised intracranial pressureDavid K. Menon
- 17.8 Sedation and analgesia in the ICUMichael C. Reade
- 17.9 Metabolic and endocrine changes in acute and chronic critical illnessEva Boonen and Greet Van den Berghe
- 17.10 Palliative and end-of-life care in the ICUPhillip D. Levin and Charles L. Sprung
- 17.11 Diagnosis of death and organ donationPaul Murphy
- 17.12 Persistent problems and recovery after critical illnessMark E. Mikkelsen and Theodore J. Iwashyna
- Section 18 Respiratory disordersEdited by Section editor: Pallav L. Shah
- 18.1 Structure and function
- 18.1.1 The upper respiratory tractPallav L. Shah, J.R. Stradling, and S.E. Craig
- 18.1.2 Airways and alveoliPeter D. Wagner and Pallav L. Shah
- 18.2 The clinical presentation of respiratory diseaseSamuel Kemp and Julian Hopkin
- 18.3 Clinical investigation of respiratory disorders
- 18.3.1 Respiratory function testsG. J. Gibson
- 18.3.2 Thoracic imagingSusan J. Copley and David M. Hansell
- 18.3.3 Bronchoscopy, thoracoscopy, and tissue biopsyPallav L. Shah
- 18.4 Respiratory infection
- 18.4.1 Upper respiratory tract infectionsP. Little
- 18.4.2 Pneumonia in the normal hostWei Shen Lim
- 18.4.3 Nosocomial pneumoniaWei Shen Lim
- 18.4.4 MycobacteriaHannah Jarvis and Onn Min Kon
- 18.4.5 Pulmonary complications of HIV infectionJulia Choy and Anton Pozniak
- 18.5 The upper respiratory tract
- 18.5.1 Upper airway obstructionJames H. Hull and Matthew Hind
- 18.5.2 Sleep-related breathing disordersMary J. Morrell, Julia Kelly, Alison McMillan, and Matthew Hind
- 18.6 Allergic rhinitisStephen R. Durham and Hesham A. Saleh
- 18.7 AsthmaAlexandra Nanzer-Kelly, Paul Cullinan, and Andrew Menzies-Gow
- 18.8 Chronic obstructive pulmonary diseaseNicholas S. Hopkinson
- 18.9 BronchiectasisR. Wilson and D. Bilton
- 18.10 Cystic fibrosisAndrew Bush and Caroline Elston
- 18.11 Diffuse parenchymal lung diseases
- 18.11.1 Diffuse parenchymal lung disease: An introductionF. Teo and A.U. Wells
- 18.11.2 Idiopathic pulmonary fibrosisP.L. Molyneaux, A.G. Nicholson, N. Hirani, and A.U. Wells
- 18.11.3 Bronchiolitis obliterans and cryptogenic organizing pneumoniaVasilis Kouranos and A.U. Wells
- 18.11.4 The lung in autoimmune rheumatic disordersM.A. Kokosi and A.U. Wells
- 18.11.5 The lung in vasculitisG.A. Margaritopoulos and A.U. Wells
- 18.12 SarcoidosisRobert P. Baughman and Elyse E. Lower
- 18.13 PneumoconiosesP.T. Reid
- 18.14 Miscellaneous conditions
- 18.14.1 Diffuse alveolar haemorrhageS. J. Bourke and G.P. Spickett
- 18.14.2 Eosinophilic pneumoniaS. J. Bourke and G.P. Spickett
- 18.14.3 Lymphocytic infiltrations of the lungS. J. Bourke
- 18.14.4 Hypersensitivity pneumonitisS. J. Bourke and G.P. Spickett
- 18.14.5 Pulmonary Langerhans’ cell histiocytosisS. J. Bourke
- 18.14.6 LymphangioleiomyomatosisS. J. Bourke
- 18.14.7 Pulmonary alveolar proteinosisS. J. Bourke
- 18.14.8 Pulmonary amyloidosisS. J. Bourke
- 18.14.9 Lipoid (lipid) pneumoniaS. J. Bourke
- 18.14.10 Pulmonary alveolar microlithiasisS. J. Bourke
- 18.14.11 Toxic gases and aerosolsChris Stenton
- 18.14.12 Radiation pneumonitisS. J. Bourke
- 18.14.13 Drug-induced lung diseaseS. J. Bourke
- 18.15 Chronic respiratory failureMichael I. Polkey and P.M.A. Calverley
- 18.16 Lung transplantationP. Hopkins and A.J. Fisher
- 18.17 Pleural diseasesD. de Fonseka, Y.C. Gary Lee, and N.A. Maskell
- 18.18 Disorders of the thoracic cage and diaphragmJohn M. Shneerson and Michael I. Polkey
- 18.19 Malignant diseases
- 18.19.1 Lung cancerS.G. Spiro and N. Navani
- 18.19.2 Pulmonary metastasesS.G. Spiro
- 18.19.3 Pleural tumoursY.C. Gary Lee
- 18.19.4 Mediastinal tumours and cystsY.C. Gary Lee and Helen E. Davies
- 18.1 Structure and function
- Section 19 Rheumatological disordersEdited by Section editor: Richard A. Watts
- 19.1 Joints and connective tissue—structure and functionThomas Pap, Adelheid Korb-Pap, Christine Hartmann, and Jessica Bertrand
- 19.2 Clinical presentation and diagnosis of rheumatological disordersChristopher Deighton and Fiona Pearce
- 19.3 Clinical investigationMichael Doherty and Peter C. Lanyon
- 19.4 Back pain and regional disordersCarlo Ammendolia and Danielle Southerst
- 19.5 Rheumatoid arthritisKenneth F. Baker and John D. Isaacs
- 19.6 Spondyloarthritis and related conditionsJürgen Braun and Joachim Sieper
- 19.7 Infection and arthritisGraham Raftery and Muddassir Shaikh
- 19.8 Reactive arthritisCarmel B. Stober and Hill Gaston
- 19.9 OsteoarthritisAndrew J. Barr and Philip G. Conaghan
- 19.10 Crystal-related arthropathiesEdward Roddy and Michael Doherty
- 19.11 Autoimmune rheumatic disorders and vasculitides
- 19.11.1 IntroductionDavid A. Isenberg and Ian Giles
- 19.11.2 Systemic lupus erythematosus and related disordersAnisur Rahman and David A. Isenberg
- 19.11.3 Systemic sclerosis (scleroderma)Christopher P. Denton and Carol M. Black
- 19.11.4 Sjögren’s syndromeWan-Fai Ng
- 19.11.5 Inflammatory myopathiesIngrid E. Lundberg, Hector Chinoy, and Robert Cooper
- 19.11.6 Large vessel vasculitisRaashid Luqmani and Cristina Ponte
- 19.11.7 ANCA-associated vasculitisDavid Jayne
- 19.11.8 Polyarteritis nodosaLoïc Guillevin
- 19.11.9 Small vessel vasculitisRichard A. Watts
- 19.11.10 Behçet’s syndromeSebahattin Yurdakul, Izzet Fresko, and Hasan Yazici
- 19.11.11 Polymyalgia rheumaticaBhaskar Dasgupta and Eric L. Matteson
- 19.11.12 Kawasaki diseaseBrian W. McCrindle
- 19.12 Miscellaneous conditions presenting to the rheumatologistStuart Carter, Lisa Dunkley, and Ade Adebajo
- Section 20 Disorders of the skeletonEdited by Section editor: Cyrus Cooper
- 20.1 Skeletal disorders—general approach and clinical conditionsB. Paul Wordsworth and M.K. Javaid
- 20.2 Inherited defects of connective tissue: Ehlers–Danlos syndrome, Marfan’s syndrome, and pseudoxanthoma elasticumN.P. Burrows
- 20.3 OsteomyelitisMartin A. McNally and Anthony R. Berendt
- 20.4 OsteoporosisNicholas C. Harvey, Juliet Compston, and Cyrus Cooper
- 20.5 Osteonecrosis, osteochondrosis, and osteochondritis dissecansGavin Clunie
- 20.6 Bone cancerHelen Hatcher
- Section 21 Disorders of the kidney and urinary tractEdited by Section editor: John D. Firth
- 21.1 Structure and function of the kidneySteve Harper and Robert Unwin
- 21.2 Electrolyte disorders
- 21.2.1 Disorders of water and sodium homeostasisMichael L. Moritz and Juan Carlos Ayus
- 21.2.2 Disorders of potassium homeostasisJohn D. Firth
- 21.3 Clinical presentation of renal diseaseRichard E. Fielding and Ken Farrington
- 21.4 Clinical investigation of renal diseaseAndrew Davenport
- 21.5 Acute kidney injuryJohn D. Firth
- 21.6 Chronic kidney diseaseAlastair Hutchison
- 21.7 Renal replacement therapy
- 21.7.1 HaemodialysisRobert Mactier
- 21.7.2 Peritoneal dialysisSimon Davies
- 21.7.3 Renal transplantationNicholas Torpey and John D. Firth
- 21.8 Glomerular diseases
- 21.8.1 Immunoglobulin A nephropathy and IgA vasculitis (HSP)Jonathan Barratt and John Feehally
- 21.8.2 Thin membrane nephropathyPeter Topham and John Feehally
- 21.8.3 Minimal-change nephropathy and focal segmental glomerulosclerosisMoin Saleem and Lisa Willcocks
- 21.8.4 Membranous nephropathyAn S. De Vriese and Fernando C. Fervenza
- 21.8.5 Proliferative glomerulonephritisAlan D. Salama and Mark A. Little
- 21.8.6 Membranoproliferative glomerulonephritisTabitha Turner-Stokes and Mark A. Little
- 21.8.7 Antiglomerular basement membrane diseaseMårten Segelmark and Thomas Hellmark
- 21.9 Tubulointerstitial diseases
- 21.9.1 Acute interstitial nephritisSimon D. Roger
- 21.9.2 Chronic tubulointerstitial nephritisMarc E. De Broe, Channa Yamasumana, Patrick C. D’Haese, Monique M. Elseviers, and Benjamin Vervaet
- 21.10 The kidney in systemic disease
- 21.10.1 Diabetes mellitus and the kidneyRudolf Bilous
- 21.10.2 The kidney in systemic vasculitisDavid Jayne
- 21.10.3 The kidney in rheumatological disordersLiz Lightstone and Hannah Beckwith
- 21.10.4 The kidney in sarcoidosisIngeborg Hilderson and Jan Donck
- 21.10.5 Renal involvement in plasma cell dyscrasias, immunoglobulin-based amyloidoses, and fibrillary glomerulopathies, lymphomas, and leukaemiasPierre Ronco, Frank Bridoux, and Arnaud Jaccard
- 21.10.6 Haemolytic uraemic syndromeEdwin K.S. Wong and David Kavanagh
- 21.10.7 Sickle cell disease and the kidneyClaire C. Sharpe
- 21.10.8 Infection-associated nephropathiesA. Neil Turner
- 21.10.9 Malignancy-associated renal diseaseA. Neil Turner
- 21.10.10 Atherosclerotic renovascular diseasePhilip A. Kalra and Diana Vassallo
- 21.11 Renal diseases in the tropicsVivekanand Jha
- 21.12 Renal involvement in genetic diseaseD. Joly and J.P. Grünfeld
- 21.13 Urinary tract infectionCharles Tomson and Neil Sheerin
- 21.14 Disorders of renal calcium handling, urinary stones, and nephrocalcinosisChristopher Pugh, Elaine M. Worcester, Andrew P. Evan, and Fredric L. Coe
- 21.15 The renal tubular acidosesJohn A. Sayer and Fiona E. Karet
- 21.16 Disorders of tubular electrolyte handlingNine V.A.M. Knoers and Elena N. Levtchenko
- 21.17 Urinary tract obstructionMuhammad M. Yaqoob and Kieran McCafferty
- 21.18 Malignant diseases of the urinary tractTim Eisen, Freddie C. Hamdy, and Robert A. Huddart
- 21.19 Drugs and the kidneyAine Burns and Caroline Ashley
- Section 22 Haematological disordersEdited by Section editors: Chris Hatton and Deborah Hay
- 22.1 Introduction to haematologyChris Hatton
- 22.2 Haematopoiesis
- 22.2.1 Cellular and molecular basis of haematopoiesisParesh Vyas and N. Asger Jakobsen
- 22.2.2 Diagnostic techniques in the assessment of haematological malignanciesWendy N. Erber
- 22.3 Myeloid disease
- 22.3.1 Granulocytes in health and diseaseJoseph Sinning and Nancy Berliner
- 22.3.2 Myelodysplastic syndromesCharlotte K. Brierley and David P. Steensma
- 22.3.3 Acute myeloid leukaemiaNigel Russell and Alan Burnett
- 22.3.4 Chronic myeloid leukaemia
Mhairi Copland and Tessa L. Holyoake - 22.3.5 The polycythaemiasDaniel Aruch and Ronald Hoffman
- 22.3.6 Thrombocytosis and essential thrombocythaemiaDaniel Aruch and Ronald Hoffman
- 22.3.7 Primary myelofibrosisEvan M. Braunstein and Jerry L. Spivak
- 22.3.8 EosinophiliaPeter F. Weller
- 22.3.9 HistiocytosisChris Hatton
- 22.4 Lymphoid disease
- 22.4.1 Introduction to lymphopoiesisCaron A. Jacobson and Nancy Berliner
- 22.4.2 Acute lymphoblastic leukaemiaH. Josef Vormoor, Tobias F. Menne, and Anthony V. Moorman
- 22.4.3 Hodgkin lymphomaVijaya Raj Bhatt and James O. Armitage
- 22.4.4 Non-Hodgkin lymphomaVijaya Raj Bhatt and James O. Armitage
- 22.4.5 Chronic lymphocytic leukaemiaClive S. Zent and Aaron Polliack
- 22.4.6 Plasma cell myeloma and related monoclonal gammopathiesS. Vincent Rajkumar and Robert A. Kyle
- 22.5 Bone marrow failure
- 22.5.1 Inherited bone marrow failure syndromesIrene Roberts and Inderjeet S. Dokal
- 22.5.2 Acquired aplastic anaemia and pure red cell aplasiaJudith C.W. Marsh, Shreyans Gandhi, and Ghulam J. Mufti
- 22.5.3 Paroxysmal nocturnal haemoglobinuriaLucio Luzzatto
- 22.6 Erythroid disorders
- 22.6.1 ErythropoiesisVijay G. Sankaran
- 22.6.2 Anaemia: pathophysiology, classification, and clinical featuresDavid J. Weatherall and Chris Hatton
- 22.6.3 Anaemia as a challenge to world healthDavid J. Roberts and David J. Weatherall
- 22.6.4 Iron metabolism and its disordersTimothy M. Cox and John B. Porter
- 22.6.5 Anaemia of inflammationSant-Rayn Pasricha and Hal Drakesmith
- 22.6.6 Megaloblastic anaemia and miscellaneous deficiency anaemiasA.V. Hoffbrand
- 22.6.7 Disorders of the synthesis or function of haemoglobinDeborah Hay and David J. Weatherall
- 22.6.8 Anaemias resulting from defective maturation of red cellsStephen J. Fuller and James S. Wiley
- 22.6.9 Disorders of the red cell membranePatrick G. Gallagher
- 22.6.10 Erythrocyte enzymopathiesAlberto Zanella and Paola Bianchi
- 22.6.11 Glucose-6-phosphate dehydrogenase deficiencyLucio Luzzatto
- 22.6.12 Acquired haemolytic anaemiaAmy Powers and Leslie Silberstein
- 22.7 Haemostasis
- 22.7.1 The biology of haemostasis and thrombosisGilbert C. White, II, Harold R. Roberts, and Nigel S. Key
- 22.7.2 Evaluation of the patient with a bleeding tendencyTrevor Baglin
- 22.7.3 Thrombocytopenia and disorders of platelet functionNicola Curry and Susie Shapiro
- 22.7.4 Genetic disorders of coagulationEleanor S. Pollak and Katherine A. High
- 22.7.5 Acquired coagulation disordersT.E. Warkentin
- 22.8 Transfusion and transplantation
- 22.8.1 Blood transfusionD.S. Giovanniello and E.L. Snyder
- 22.8.2 Haemopoietic stem cell transplantationE.C. Gordon-Smith and Emma C. Morris
- Section 23 Disorders of the skinEdited by Section editor: Roderick J. Hay
- 23.1 Structure and function of skinJohn A. McGrath
- 23.2 Clinical approach to the diagnosis of skin diseaseVanessa Venning
- 23.3 Inherited skin diseaseThiviyani Maruthappu and David P. Kelsell
- 23.4 Autoimmune bullous diseasesKathy Taghipour and Fenella Wojnarowska
- 23.5 Papulosquamous diseaseChristopher E.M. Griffiths
- 23.6 Dermatitis/eczemaPeter S. Friedmann, Michael J. Arden-Jones, and Roderick J. Hay
- 23.7 Cutaneous vasculitis, connective tissue diseases, and urticariaVolha Shpadaruk and Karen E. Harman
- 23.8 Disorders of pigmentationEugene Healy
- 23.9 PhotosensitivityHiva Fassihi and Jane McGregor
- 23.10 Infections of the skinRoderick J. Hay
- 23.11 Sebaceous and sweat gland disordersAlison M. Layton
- 23.12 Blood and lymphatic vessel disordersPeter S. Mortimer and Roderick J. Hay
- 23.13 Hair and nail disordersDavid de Berker
- 23.14 Tumours of the skinEdel O’Toole
- 23.15 Skin and systemic diseasesClive B. Archer and Charles M.G. Archer
- 23.16 Cutaneous reactions to drugsSarah Walsh, Daniel Creamer, and Haur Yueh Lee
- 23.17 Management of skin diseaseRod Sinclair
- Section 24 Neurological disordersEdited by Section editor: Christopher Kennard
- 24.1 Introduction and approach to the patient with neurological diseaseAlastair Compston and Christopher Kennard
- 24.2 Mind and brain: Building bridges between neurology, psychiatry, and psychologyAdam Zeman
- 24.3 Clinical investigation of neurological disease
- 24.3.1 Lumbar punctureR. Rhys Davies and Andrew J. Larner
- 24.3.2 Electrophysiology of the central and peripheral nervous systems
Christian Krarup - 24.3.3 Imaging in neurological diseasesAndrew J. Molyneux, Shelley Renowden, and Marcus Bradley
- 24.3.4 Investigation of central motor pathways: Magnetic brain stimulationK.R. Mills
- 24.4 Higher cerebral function
- 24.4.1 Disturbances of higher cerebral functionPeter J. Nestor
- 24.4.2 Alzheimer’s disease and other dementias
Jonathan M. Schott
- 24.5 Epilepsy and disorders of consciousness
- 24.5.1 Epilepsy in later childhood and adulthoodArjune Sen and M.R. Johnson
- 24.5.2 NarcolepsyMatthew C. Walker
- 24.5.3 Sleep disordersPaul J. Reading
- 24.5.4 SyncopeAndrew J. Larner
- 24.5.5 The unconscious patientDavid Bates
- 24.5.6 Brainstem death and prolonged disorders of consciousnessAri Ercole, Peter J. Hutchinson, and John D. Pickard
- 24.6 Disorders of the special senses
- 24.6.1 Visual pathwaysSara Ajina and Christopher Kennard
- 24.6.2 Eye movements and balanceMichael Strupp and Thomas Brandt
- 24.6.3 Hearing lossLinda Luxon
- 24.7 Disorders of movement
- 24.7.1 Subcortical structures: The cerebellum, basal ganglia, and thalamusMark J. Edwards and Penelope Talelli
- 24.7.2 Parkinsonism and other extrapyramidal diseasesElisaveta Sokolov, Vinod K. Metta, and K. Ray Chaudhuri
- 24.7.3 Movement disorders other than Parkinson’s diseaseBettina Balint and Kailash Bhatia
- 24.7.4 Ataxic disordersNicholas Wood
- 24.8 HeadachePeter J. Goadsby
- 24.9 Brainstem syndromesDavid Bates
- 24.10 Specific conditions affecting the central nervous system
- 24.10.1 Stroke: Cerebrovascular diseaseJ. van Gijn (revised by Peter M. Rothwell)
- 24.10.2 Demyelinating disorders of the central nervous systemAlasdair Coles and Siddharthan Chandran
- 24.10.3 Traumatic brain injuryTim Lawrence and Laurence Watkins
- 24.10.4 Intracranial tumoursJeremy Rees
- 24.10.5 Idiopathic intracranial hypertensionAlexandra Sinclair
- 24.11 Infections of the central nervous system
- 24.11.1 Bacterial infections
Diederik van de Beek and Guy E. Thwaites - 24.11.2 Viral infectionsFiona McGill, Jeremy Farrar, Bridget Wills, Menno De Jong, David A. Warrell, and Tom Solomon
- 24.11.3 Intracranial abscessesTim Lawrence and Richard S.C. Kerr
- 24.11.4 Neurosyphilis and neuro-AIDSHadi Manji
- 24.11.5 Human prion diseasesSimon Mead and R.G. Will
- 24.11.1 Bacterial infections
- 24.12 Disorders of cranial nervesRobert D.M. Hadden
- 24.13 Disorders of the spinal cord
- 24.13.1 Diseases of the spinal cordAnu Jacob and Andrew J. Larner
- 24.13.2 Spinal cord injury and its managementWagih El Masri(y) and Michael Barnes
- 24.14 Diseases of the autonomic nervous systemChristopher J. Mathias and David A. Low
- 24.15 The motor neuron diseasesTom Jenkins, Alice Brockington, and Pamela J. Shaw
- 24.16 Diseases of the peripheral nervesRobert D.M. Hadden
- 24.17 Inherited neurodegenerative diseasesSwati Sathe
- 24.18 Disorders of the neuromuscular junctionDavid Hilton-Jones and Jacqueline Palace
- 24.19 Disorders of muscle
- 24.19.1 Structure and function of muscleMichael G. Hanna and Enrico Bugiardini
- 24.19.2 Muscular dystrophyKate Bushby and Chiara Marini-Bettolo
- 24.19.3 MyotoniaDavid Hilton-Jones
- 24.19.4 Metabolic and endocrine disordersDavid Hilton-Jones and Richard Edwards
- 24.19.5 Mitochondrial diseasePatrick F. Chinnery and D.M. Turnbull
- 24.20 Developmental abnormalities of the central nervous systemChristopher M. Verity, Jane A. Hurst, and Helen V. Firth
- 24.21 Acquired metabolic disorders and the nervous systemNeil Scolding
- 24.22 Neurological complications of systemic diseaseNeil Scolding
- 24.23 Paraneoplastic neurological syndromesJeremy Rees
- 24.24 Autoimmune encephalitis and Morvan’s syndromeCamilla Buckley and Angela Vincent
- Section 25 Disorders of the eyeEdited by Section editor: Christopher P. Conlon
- 25.1 The eye in general medicineTasanee Braithwaite, Richard W. Lee, and Peng T. Khaw
- Section 26 Psychiatric and drug-related disordersEdited by Section editor: Michael Sharpe
- 26.1 General introductionMichael Sharpe
- 26.2 The psychiatric assessment of the medical patientJane Walker, Roger Smyth, and Michael Sharpe
- 26.3 Common psychiatric presentations in medical patients
- 26.3.1 ConfusionBart Sheehan and Thomas Jackson
- 26.3.2 Self-harmKate E.A. Saunders and Keith Hawton
- 26.3.3 Medically unexplained symptomsMichael Sharpe
- 26.3.4 Low moodJane Walker
- 26.4 Psychiatric treatments in the medically ill
- 26.4.1 Psychopharmacology in medical practicePhilip J. Cowen
- 26.4.2 Psychological treatmentsMichael Sharpe and Simon Wessely
- 26.5 Specific psychiatric disorders
- 26.5.1 DeliriumBart Sheehan
- 26.5.2 DementiaBart Sheehan
- 26.5.3 Organic psychosesCurtis McKnight and Jason Caplan
- 26.5.4 Alcohol misuseJonathan Wood
- 26.5.5 Substance misuseStephen Potts
- 26.5.6 Depressive disorderJoseph Cerimele and Lydia Chwastiak
- 26.5.7 Bipolar disorderKate E.A. Saunders and John Geddes
- 26.5.8 Anxiety disordersTed Liao and Steve Epstein
- 26.5.9 Acute stress disorder, adjustment disorders, and post-traumatic stress disorderJonathan I. Bisson
- 26.5.10 Eating disordersChristopher G. Fairburn
- 26.5.11 SchizophreniaStephen M. Lawrie
- 26.5.12 Somatic symptom and related disordersMichael Sharpe
- 26.5.13 Personality disordersIain Jordan
- 26.6 Changing unhealthy behaviours
- 26.6.1 Brief interventions for excessive alcohol consumptionAmy O’Donnell, Eileen Kaner, and Nick Heather
- 26.6.2 Obesity and weight managementSusan Jebb and Paul Aveyard
- 26.6.3 Smoking cessationPaul Aveyard
- 26.7 Psychiatry, liaison psychiatry, and psychological medicineMichael Sharpe
- Section 27 Forensic medicineEdited by Section editor: John D. Firth
- 27.1 Forensic and legal medicineJason Payne-James, Paul Marks, Ralph Bouhaidar, and Steven B. Karch
- Section 28 Sport and exercise medicineEdited by Section editor: John D. Firth
- 28.1 Sport and exercise medicineCathy Speed
- Section 29 Biochemistry in medicineEdited by Section editor: Christopher P. Conlon
- 29.1 The use of biochemical analysis for diagnosis and managementBrian Shine and Nishan Guha
- Section 30 Acute medicineEdited by Section editor: John D. Firth
- 30.1 Acute medical presentationsSian Coggle, Elaine Jolly, and John D. Firth
- 30.2 Practical proceduresElaine Jolly, Sian Coggle, and John D. Firth
- End Matter
