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Transplantation immunology 

Transplantation immunology
Chapter:
Transplantation immunology
Author(s):

James F. George

DOI:
10.1093/med/9780198734871.003.0004
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date: 23 September 2019

The tendency of most complex organisms, especially mammals, is to reject transplants of vascularized and nonvascularized organs due to an immune response. The immune system will therefore destroy a transplanted heart unless steps are taken to inhibit its response to the heart. This chapter provides an in-depth discussion of what the immune system does in the context of solid organ transplantation and the anatomy of the immune system and how it works, defining immune response and providing history of our medical understanding of immunity. It goes on to provide detail of recognition of donor antigens and antigen processing, T cells and the T-cell receptor, B cells, characteristics of antibody response, NK cells, cytokines, adhesion molecules, activation of the immune response after heart transplantation, and the role of innate immunity.

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