- Foreword
- Contributors
- Abbreviations
- Chapter 1 Advanced heart failure in perspective
- Chapter 2 Cell biology of heart failure
- Chapter 3 Physiology and hemodynamic assessment of the failing heart: Current knowledge and unmet needs for advanced heart failure
- Chapter 4 Transplantation immunology
- Chapter 5 Implantable devices for cardiovascular monitoring
- Chapter 6 Endomyocardial biopsy in the failing heart
- Chapter 7 Imaging in advanced heart failure
- Chapter 8 Pharmacologic management of advanced heart failure
- Chapter 9 Arrhythmias in heart failure: The atrioventricular node and above
- Chapter 10 Ventricular arrhythmias in heart failure
- Chapter 11 Cardiac resynchronization
- Chapter 12 Advanced heart failure in valvular heart disease
- Chapter 13 High-risk heart failure surgery: Strategies for coronary artery bypass grafting and valve surgery in patients with reduced ejection fraction
- Chapter 14 Mechanical circulatory support: Patient selection, optimization, and in-patient management of the patient with a left ventricular assist device
- Chapter 15 Mechanical circulatory support: Outpatient management
- Chapter 16 Cardiac transplantation: Overview
- Chapter 17 Immunosuppression strategies
- Chapter 18 Rejection surveillance: Types and treatment
- Chapter 19 Complications after cardiac transplantation
- Chapter 20 Right heart failure: Anatomy, physiology, and pathobiology
- Chapter 21 Right ventricular failure: Clinical features and management
- Chapter 22 Pulmonary arterial hypertension
- Chapter 23 End of life care in advanced heart failure
- Chapter 24 Future directions in advanced heart failure
- Index
(p. 12) Cell biology of heart failure
- Chapter:
- (p. 12) Cell biology of heart failure
- Author(s):
Kenneth B. Margulies
and J. Eduardo Rame
- DOI:
- 10.1093/med/9780198734871.003.0002
In many etiologies of heart failure there is a reduction of the normal number of cardiac myocotes, and the syndrome is consistently associated with both qualitative and quantitative changes in these cells. This chapter describes the triggers, phenomena, and mechanisms associated with the transitions away from normal cardiac myocyte structure and function during pathological remodeling of the heart. Morphological adaptations of cardiac myocytes, the regulation of cardiac contractility, cardiac metabolism, and alternative cell death pathways activated in failing hearts are considered. The reversibility of cardiac myocyte hypertrophy and dysfunction that has been demonstrated in in recent years is also highlighted. These reverse remodeling phenomena demonstrate the substantial plasticity of the severely failing heart, providing insights into factors driving and sustaining pathological adaptations and attesting to the potential benefit of importance of therapeutic interventions targeting the failing heart.
Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.
Please subscribe or login to access full text content.
If you have purchased a print title that contains an access token, please see the token for information about how to register your code.
For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.
- Foreword
- Contributors
- Abbreviations
- Chapter 1 Advanced heart failure in perspective
- Chapter 2 Cell biology of heart failure
- Chapter 3 Physiology and hemodynamic assessment of the failing heart: Current knowledge and unmet needs for advanced heart failure
- Chapter 4 Transplantation immunology
- Chapter 5 Implantable devices for cardiovascular monitoring
- Chapter 6 Endomyocardial biopsy in the failing heart
- Chapter 7 Imaging in advanced heart failure
- Chapter 8 Pharmacologic management of advanced heart failure
- Chapter 9 Arrhythmias in heart failure: The atrioventricular node and above
- Chapter 10 Ventricular arrhythmias in heart failure
- Chapter 11 Cardiac resynchronization
- Chapter 12 Advanced heart failure in valvular heart disease
- Chapter 13 High-risk heart failure surgery: Strategies for coronary artery bypass grafting and valve surgery in patients with reduced ejection fraction
- Chapter 14 Mechanical circulatory support: Patient selection, optimization, and in-patient management of the patient with a left ventricular assist device
- Chapter 15 Mechanical circulatory support: Outpatient management
- Chapter 16 Cardiac transplantation: Overview
- Chapter 17 Immunosuppression strategies
- Chapter 18 Rejection surveillance: Types and treatment
- Chapter 19 Complications after cardiac transplantation
- Chapter 20 Right heart failure: Anatomy, physiology, and pathobiology
- Chapter 21 Right ventricular failure: Clinical features and management
- Chapter 22 Pulmonary arterial hypertension
- Chapter 23 End of life care in advanced heart failure
- Chapter 24 Future directions in advanced heart failure
- Index