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Rejection surveillance: Types and treatment 

Rejection surveillance: Types and treatment
Chapter:
Rejection surveillance: Types and treatment
Author(s):

Natasha Lipson Altman

and Sean P. Pinney

DOI:
10.1093/med/9780198734871.003.0018
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date: 18 October 2019

Long-term survival following heart transplantation has been achieved through refinements in patient and donor selection and in postoperative management. The development of immune suppression has been of crucial importance to this field, transforming heart transplantation from a curiosity to its present position as the therapy of choice for advanced heart failure. Immune surveillance is therefore a primary role of the transplant physician, specifically balancing the risk of allograft rejection against treatment-related adverse events, specifically infection, renal dysfunction, and other side effects. This chapter considers the cause and frequency of rejection before exploring endomyocardial biopsy, gene expression profiling, types of assessment and monitoring, and treatment.

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