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Extra-articular manifestations: uveitis 

Extra-articular manifestations: uveitis
Extra-articular manifestations: uveitis

James T. Rosenbaum

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date: 05 August 2020

Acute anterior uveitis (AAU) is the most common, extra-articular, clinical manifestation of spondyloarthritis. In some patients, it is the dominant manifestation. This chapter reviews the definition of uveitis, the epidemiology of uveitis, the differential diagnosis, the relationship of HLA-B27 to uveitis, laboratory testing for suspected HLA-B27-associated uveitis, treatment considerations, and experimental models in which both uveitis and spondylitis co-exist. Although acute anterior uveitis rarely precedes spondyloarthritis, acute anterior uveitis is often the clue that chronic back pain is due to sacroiliac inflammation. Uveitis is sometimes the dominant clinical manifestation of spondyloarthritis and it can influence the choice for appropriate therapy.

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