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Juvenile-onset spondyloarthritis 

Juvenile-onset spondyloarthritis
Juvenile-onset spondyloarthritis

Ruben Burgos-Vargas

and Shirley M.L. Tse

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date: 20 September 2020

Juvenile-onset spondyloarthritis (JoSpA) refers to the group of HLA-B27-associated paediatric rheumatic diseases that involves the synovium and entheses of peripheral joints in the initial years and, in some patients, the sacroiliac and spinal joints several years later. Patients with JoSpA may also have extra-articular manifestations, including anterior uveitis, psoriasis and inflammatory bowel disease (IBD), and this represents a disease continuum with adult-onset SpA. JoSpA might include patients with enthesitis-related arthritis (ERA) and PsA categories of juvenile idiopathic arthritis (JIA), according to the International League of Associations for Rheumatology (ILAR). The opposite does not occur, since ILAR JIA classification does not allow the possibility of clinical overlapping among the different categories, one of the most important features of SpA.

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