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Pharmacology of antipsychotic long-acting injections 

Pharmacology of antipsychotic long-acting injections
Pharmacology of antipsychotic long-acting injections

Tim Lambert

and David Taylor

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date: 15 July 2019

This chapter provides an overview of the pharmacology of first-generation and second-generation antipsychotic long-acting injections (LAIs). The pharmacokinetics of LAIs and how these influence clinical use are discussed. This includes an examination of dosage, injection intervals, and the use of loading or initiation strategies to speed up the attainment of steady-state plasma levels following initiation of treatment. The chapter considers the pharmacodynamics of different LAIs and switching to and from LAIs. The main aim of the chapter is to provide sufficient information to allow a clinician to understand the main differences between long-acting agents and to set the scene for an evidence-based approach to prescribing.

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