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Gonococcal infection 

Gonococcal infection
Chapter:
Gonococcal infection
DOI:
10.1093/med/9780198729228.003.0067
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date: 19 November 2019

Since the first use of the term haemolytic–uraemic syndrome (HUS) for children with renal failure, haemolytic anaemia, and thrombocytopenia, the pathogenesis of the disease has been studied tremendously. In the mid eighties of the twentieth century, shiga-like toxin-producing Escherichia coli (STEC) was identified as the main cause of diarrhoea-associated HUS. Twenty years later, the role of the complement system as aetiology in atypical HUS (aHUS) was clearly demonstrated. In childhood, STEC-HUS and complement-mediated HUS, here called aHUS, are the main causes of HUS, together with HUS induced by Streptococcus pneumoniae infection (SP-HUS). In this chapter, the different forms of HUS and their characteristics are being reviewed

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