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Hereditary autoinflammatory diseases 

Hereditary autoinflammatory diseases
Chapter:
Hereditary autoinflammatory diseases
DOI:
10.1093/med/9780198729228.003.0024
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date: 18 November 2019

Pyrexia of unknown origin (PUO) remains a great challenge due to its wide differential diagnosis. PUO is not a common paediatric problem. Children with persistent fever may have a serious underlying disease. Early diagnosis of these conditions is important. The main conditions which present as PUO are infections, non-infectious inflammatory conditions, and malignancies. Paediatricians need to rely on a detailed history, clinical examination, and pattern recognition in managing these patients. Since there are over a hundred causes of PUO, investigations need to be directed according to the history and clinical examination. Despite recent advances, there are significant proportions of cases where a diagnosis is not made.

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