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Immunocompromised children with infection 

Immunocompromised children with infection
Chapter:
Immunocompromised children with infection
DOI:
10.1093/med/9780198729228.003.0017
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date: 26 June 2019

Rapidly changing vaccination schedules, along with a growing number of immunocompromised children, mean clinicians increasingly have to decide on the relative risks and benefits of giving vaccines to immunocompromised children. Very often, the central dilemma is that the children who could potentially benefit most from vaccine protection are those for whom vaccines may be least effective or potentially dangerous. In general, immunocompromised children: should receive all routinely recommended non-live vaccines; may be eligible for additional, non-live vaccines; may respond less well to vaccination than healthy children and may therefore require additional doses of vaccines; should generally avoid live vaccines if they have significant immunocompromise—but live vaccines can be considered in specific circumstances; require consideration of exposure reduction, e.g. by immunizing family members; may benefit from passive immunization in specific circumstances (see specific chapters for measles, respiratory syncytial virus, and varicella).

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