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Alternatives to generic preference-based measures: mapping, condition-specific measures, bolt-ons, vignettes, direct utility assessment, and well-being 

Alternatives to generic preference-based measures: mapping, condition-specific measures, bolt-ons, vignettes, direct utility assessment, and well-being
Chapter:
Alternatives to generic preference-based measures: mapping, condition-specific measures, bolt-ons, vignettes, direct utility assessment, and well-being
Author(s):

John Brazier

, Julie Ratcliffe

, Joshua A. Salomon

, and Aki Tsuchiya

DOI:
10.1093/med/9780198725923.003.0008
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date: 30 June 2022

This chapter describes the methods and critically reviews the alternatives to generic preference-based measures (GPBMs) of health. Although there is considerable evidence for the validity and responsiveness of GPBMs in many conditions, but despite this, in these conditions they are often not used in clinical trials. Furthermore, GPBMs have been shown to be insensitive for some conditions. One alternative is to map from other health or clinical measures on to one of the GPBMs. Another is to devise a more relevant condition-specific preference-based measure, or use a bespoke vignette (scenario) describing the impact of the condition. A variant of this approach would be to add extra dimensions to GPBMs in order to improve their relevance to some conditions. Finally, there has been a growing interest in the measurement of well-being to help extend the descriptive component beyond health and the values to better reflect experience rather than preferences.

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