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The Pharmaceutical Phoenix Rises 

The Pharmaceutical Phoenix Rises
The Pharmaceutical Phoenix Rises

Dieter Schmidt

and Simon Shorvon

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date: 26 October 2020

This chapter considers the evolution of drug therapy between 1860 and 1970, a period dominated by five compounds: bromide, phenobarbital, phenytoin, carbamazepine, and valproate. These drugs have changed the lives of people with epilepsy for the better, more perhaps than any other treatment, before or since, and deserve to be celebrated. With the possible exception of phenytoin, the antiepileptic properties of these drugs were detected largely by chance. Each though each was a child of its time, each has had both positive and negative features. These were landmarks in reducing and ameliorating seizures as a symptom of epilepsy, but are not a cure of the disease.

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