Show Summary Details
Page of

ADHD pathogenesis 

ADHD pathogenesis
ADHD pathogenesis

Edmund Sonuga-Barke

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2021. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 October 2021

ADHD has a complex etiology. Multiple genetic common and rare variants and early operating environmental risk factors of small effect act and interact to create a spectrum of neurobiological liability. Brain structure and function is disrupted in subtle ways across multiple systems that regulate both intrinsic spontaneous and extrinsic task-elicited cognition and action. ADHD performance can be normalized in certain contexts, highlighting the importance of motivational and energetic processes. ADHD is not a single pathophysiological entity, with growing evidence for different subgroups of individual patients with different pathogenic and cognitive deficit profiles.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.