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Vitamin D in pregnancy and breastfeeding 

Vitamin D in pregnancy and breastfeeding
Chapter:
Vitamin D in pregnancy and breastfeeding
Author(s):

Sir Peter Gluckman

, Mark Hanson

, Chong Yap Seng

, and Anne Bardsley

DOI:
10.1093/med/9780198722700.003.0015
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date: 01 March 2021

Vitamin D, which is synthesized in skin exposed to UV light, or is consumed in the diet, plays a key role in maintaining bone integrity via the regulation of calcium and phosphorus homeostasis. It also influences a number of extra-skeletal processes, including immune function and blood glucose homeostasis. Maternal vitamin D deficiency in pregnancy leads to poor fetal skeletal mineralization in utero that can manifest as rickets in newborns. In addition to skeletal effects, women with very low vitamin D status face increased risks of other adverse pregnancy outcomes and possible long-term effects on their own health and that of their offspring. However, controversy remains over definitions of vitamin D sufficiency and deficiency, complicating recommendations on maternal intakes. At a minimum, all pregnant women should take a supplement of 400 IU/day, in addition to sensible sun exposure and increasing their intake of food sources.

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