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Saranya Sridhar

and Ibrahim Abubakar

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date: 28 July 2021

Broadly, sero-epidemiology is the use of immunological tools, particularly serology, to measure population immunity in order to assess the epidemiology of health and disease. This chapter begins by providing an overview of the immune system and its response to infection. It details the commonest immune assays and analysis of immunological data and issues produced by their use in sero-epidemiological studies. The public health applications for sero-epidemiological studies are described, the different study designs detailed and the sources of bias, limitations, and advantages of each study design illustrated with examples. The chapter highlights some of the emerging developments in methods, techniques, and assays that will impact on future sero-epidemiological studies.

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