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Cannabis 

Cannabis
Chapter:
Cannabis
DOI:
10.1093/med/9780198714750.003.0010
Page of

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date: 15 November 2019

Chapter 10 of Addiction Medicine covers the epidemiology, pharmacology, and clinical syndromes related to cannabis use and provides an outline of management for cannabis use disorders. Numerous cannabinoid drugs have been identified of which delta-9-tetrahydrocannabinol (THC) and cannabidiol are the commonest in naturally occurring cannabis (marijuana). Synthetic cannabinoids have also been produced in recent years and they have distinctly different properties. A summary is provided on the THC content of different cannabis preparations and on the pharmacological effects of the main constituents. Core clinical syndromes such as acute intoxication, cannabis dependence, and cannabis withdrawal are outlined. Medical and traumatic complications, and neuropsychiatric complications are described. There are detailed accounts of acute and chronic psychoses related to cannabis use. Approaches to clinical assessment and diagnosis are offered. Following an outline of a brief intervention approach for risky use, detailed clinical protocols are provided for withdrawal management and the longer-term management of cannabis dependence.

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