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Simultaneous Macro- and Microrecordings 

Simultaneous Macro- and Microrecordings
Simultaneous Macro- and Microrecordings

Michal T. Kucewicz

, B. Michael Berry

, and Gregory A. Worrell

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date: 11 July 2020

Invasive recordings from patients with epilepsy are increasingly employing new hybrid electrode technologies, which combine macro- and microelectrode electrophysiology, to explore the large scope of brain processes. These range from action potentials of single neurons to coordinated activity of neuronal ensembles to oscillations of widespread brain networks, all buried in oscillations of the extracellular local field potential sampled at various spatiotemporal scales. This chapter reviews various approaches to simultaneous micro- and macroscale electrophysiology, with current electrode designs and applications being discussed together with particular examples of epilepsy pathophysiology. The chapter highlights the advantages, limitations, and challenges for new technologies in the emerging era of human brain mapping projects. It is this technological advance that drives the progress of human intracranial electrophysiology and shifts attention to a vast scale of neuronal networks.

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