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Therapeutic Stimulation of the Ictal Onset Zone 

Therapeutic Stimulation of the Ictal Onset Zone
Therapeutic Stimulation of the Ictal Onset Zone

Mathieu Sprengers

, Sofie Carrette

, Kristl Vonck

, and Paul Boon

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date: 13 July 2020

Brain stimulation has emerged as an alternative treatment for patients with refractory epilepsy and an increasing number of trials evaluating its efficacy and safety have been published. Various brain structures have been targeted, focusing either on the ictal onset zone or on remote epileptogenic network structures. This chapter focuses on stimulation of the ictal onset zone. The rationale for these targets and the results obtained in open-label and randomized controlled trials (RCTs), when available, are discussed. It is concluded that promising results have been published, although mainly in open-label trials. More RCTs are needed to establish the value of ictal onset stimulation for the treatment of epilepsy.

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