Show Summary Details
Page of

Cortico-Cortical Evoked Potential Mapping 

Cortico-Cortical Evoked Potential Mapping
Chapter:
Cortico-Cortical Evoked Potential Mapping
Author(s):

Riki Matsumoto

, and Takeharu Kunieda

DOI:
10.1093/med/9780198714668.003.0032
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 24 August 2019

The utility of single-pulse electrical stimulation (SPES) for epilepsy surgery has been highlighted in the last decade. When applied at a frequency of about 1 Hz, it can probe cortico-cortical connections by averaging electrocorticographic signal time-locked to stimuli to record cortico-cortical evoked potentials (CCEPs) emanating from adjacent and remote cortices. Although limited to patients undergoing invasive presurgical evaluations, CCEPs provide a novel way to explore inter-regional connectivity in vivo in the living human brain to probe functional brain networks such as language and cognitive motor networks. In addition to its impact on basic systems neuroscience, this method, in combination with 50 Hz electrical cortical stimulation, can contribute clinically to the mapping of functional brain systems by tracking cortico-cortical connections among functional cortical regions in individual patients. This approach may help identify normal cortico-cortical networks in pathological brain, or plasticity of brain systems in conjunction with pathology. Because of its high practical value, it has been applied to intraoperative monitoring of functional brain networks in patients with brain tumours. With regard to epilepsy, SPES has been used to probe cortical excitability of the focus (epileptogenicity) and seizure networks. Both early (i.e. CCEP) and delayed responses are regarded as surrogate markers of epileptogenicity. With regard to its potential impact on human brain connectivity maps, worldwide collaboration is warranted to establish standardized CCEP connectivity maps as a solid reference for non-invasive connectome research.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.