Show Summary Details
Page of

Invasive EEG in Grey Matter Heterotopia 

Invasive EEG in Grey Matter Heterotopia
Chapter:
Invasive EEG in Grey Matter Heterotopia
Author(s):

Roberto Mai

, and Laura Tassi

DOI:
10.1093/med/9780198714668.003.0018
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 October 2019

Grey matter heterotopias (GMH) are in the malformations of cortical development group of disorders, comprising an entity of abnormal neuronal migration, triggering patterns of cortical and neuronal disarrangement. Normal but misplaced tissue within the original organ characterizes heterotopias. They share the same signal intensity as adjacent cortical grey matter, are bilateral or unilateral, diffuse or localized, with subependymal, subcortical, or transmantle localization. Genetic causes are common, particularly in bilateral cases. Drug-resistant epilepsy is the main symptom; surgery should be planned early. Invasive recordings are considered mandatory, and stereo-EEG is the most suitable exploration methodology. Both GMH and surrounding cortices may originate discharges. Surgery demonstrates good results, especially when a lesionectomy (even when incomplete) is associated with a corticectomy. Recently, thermocoagulation of the GMH and cortices encompassed within the epileptogenic zone has provided a therapeutic approach in selected, even bilateral, cases. Laser interstitial thermal therapy needs further evaluation in these patients.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.