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Bisphosphonates 

Bisphosphonates
Chapter:
Bisphosphonates
Author(s):

Richard W. Keen

DOI:
10.1093/med/9780198713340.003.0007
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date: 23 September 2020

• Bisphosphonates are potent inhibitors of bone resorption.

• Bisphosphonates are the first-line treatment for the majority of patients with osteoporosis.

• Oral bisphosphonates have a complex dosing schedule, and this has led to the development of intermittent dosing (weekly and monthly) in an attempt to improve compliance.

• Intravenous administration of bisphosphonates offers an alternative to patients with a history of upper gastrointestinal disease, malabsorption, or where compliance with oral therapy is poor.

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