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Osteoporosis risk assessment 

Osteoporosis risk assessment
Osteoporosis risk assessment

Christopher Holroyd

, Cyrus Cooper

, and Elaine Dennison

Page of

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date: 26 November 2020

Epidemiological studies from North America have estimated the remaining lifetime risk of common fragility fractures to be 17.5% for hip fracture, 15.6% for clinically diagnosed vertebral fracture, and 16% for distal forearm fracture among white women aged 50 years.

The IOF and WHO now recommend that the risk of fracture should be expressed as a short-term absolute risk, i.e. probability of fracture over a 10-year period, to help inform regarding therapies.

Some risk factors for fragility fracture act through bone mineral density (BMD), while a number of others contribute significantly to fracture risk over and above their association with BMD.

Some risk factors vary in importance, according to age.

The FRAX tool, which incorporates clinical risk factors, together with age and bone mineral density (BMD), allows the 10-year absolute risk of hip and major osteoporotic fracture to be predicted.

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