Show Summary Details
Page of

Osteoporosis, osteodystrophy, and CKD-MBD in renal disease 

Osteoporosis, osteodystrophy, and CKD-MBD in renal disease
Osteoporosis, osteodystrophy, and CKD-MBD in renal disease

Brian Camilleri

and Gavin Clunie

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2020. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 26 November 2020

Chronic kidney disease-mineral and bone disorders (CKD-MBD) describes the broader clinical syndrome encompassing mineral, bone, and calcific cardiovascular abnormalities that develop as a complication of CKD. The term renal osteodystrophy (ROD) should be restricted to the abnormalities of bone associated with CKD.

Abnormalities in bone turnover prevail in ROD, with high turnover due to secondary or tertiary hyperparathyroidism at one end of the spectrum and low turnover, such as adynamic bone disease and osteomalacia, at the other end.

ROD is an important cause of morbidity, decreased quality of life, and increased risk of fractures.

With more advanced stages of chronic kidney disease, management focusses on maintaining optimal levels of phosphorus, calcium, and PTH.

Osteoporosis in CKD stages 1–3 is managed as in the general population. The situation with stages 4 and 5 remains uncertain, owing to lack of fracture end-point studies.

There is an increased risk of fractures after renal transplantation. This is mainly related to glucocorticoid (GC) use.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.