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Parathyroid hormone 

Parathyroid hormone
Chapter:
Parathyroid hormone
Author(s):

Richard W. Keen

DOI:
10.1093/med/9780198713340.003.0010
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date: 23 September 2020

Parathyroid hormone (PTH) is the first ‘anabolic’ treatment available for the management of osteoporosis.

PTH is given as a daily subcutaneous injection.

Teriparatide (recombinant human PTH 1–34) 20 μg/day has been demonstrated to reduce the risk of vertebral and non-vertebral fractures, whereas Preotact® (recombinant human PTH 1–84) 100 μg/day has only been demonstrated to reduce the risk of vertebral fractures.

PTH therapy stimulates bone turnover, with a predominant effect on osteoblast function. This causes a significant increase in bone formation, leading to gains in bone mass, improvements in skeletal microarchitecture, and increases in cortical thickness.

Treatment with PTH is generally safe and well tolerated.

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