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The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders 

The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders
Chapter:
The influence of psychiatric and medical comorbidities in treatment resistance for mood disorders
Author(s):

Sheng-Min Wang

and Chi-Un Pae

DOI:
10.1093/med/9780198707998.003.0004
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date: 20 February 2020

Mood disorders are chronic and severe mental health conditions which are frequently encountered in routine clinical practice. They present with diverse symptoms and varying clinical courses potentially resulting in personal impairment, occupational dysfunction, and economic burden. Antidepressants, antipsychotics, anxiolytics, and mood stabilizers are available treatments. However, response and remission rates with approved treatment agents are still inadequate due to the complex pathophysiology and diverse natural history of mood disorders. In this context, psychiatric and medical comorbidities are prevailing hallmarks of mood disorders, and are associated with a worse long-term clinical course. This chapter provides a comprehensive review of the extant literature on the influence of these comorbidities on treatment resistance in mood disorders. Furthermore, practical and clinical implications are summarized and future research directions are presented.

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