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Treatment-resistant major depressive disorder: current definitions, epidemiology, and assessment 

Treatment-resistant major depressive disorder: current definitions, epidemiology, and assessment
Chapter:
Treatment-resistant major depressive disorder: current definitions, epidemiology, and assessment
Author(s):

Marcelo T Berlim

, Santiago Tovar-Perdomo

, and Marcelo PA Fleck

DOI:
10.1093/med/9780198707998.003.0001
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date: 03 July 2022

Treatment-resistant depression (TRD) is a common problem in clinical practice, yet there is a significant lack of consistency in its conceptualization. Different attempts to provide a formal classification to TRD have resulted in a highly heterogeneous body of research in this topic. This chapter revises currently held concepts on TRD, including several proposed classification and staging systems, its epidemiology and psychosocial impact as well as the basic clinical assessment of depressed patients with putative resistance to treatment.

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