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Pathophysiology of hypertension 

Pathophysiology of hypertension
Chapter:
Pathophysiology of hypertension
Author(s):

Sunil Nadar

DOI:
10.1093/med/9780198701972.003.0002
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date: 28 June 2022

Hypertension is a complex disease with many factors contributing to its development and maintenance. Increased circulatory volume and increased peripheral resistance are the main pathophysiological mechanisms. The renin-angiotensin-aldosterone system along with abnormalities in the renal tubules also plays a part. Endothelial activation, dysfunction, and damage that are seen in hypertension are both causes and effects of the raised blood pressure and contribute significantly to the maintenance of high blood pressure.

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