Show Summary Details
Page of

Biological significance of gut microbiota changes associated with ageing 

Biological significance of gut microbiota changes associated with ageing
Biological significance of gut microbiota changes associated with ageing

Kevin Horgan

, Fergus Shanahan

, and Paul W. O’Toole

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 21 May 2022

The concept that the commensal gut microbiota might influence the ageing process is not new. Awareness of the gastrointestinal microbiota and its potential role in host health was recognized in the late nineteenth century. Metchnikoff was a proponent of the value of fermented foods in promoting healthy ageing and proposed that the beneficial effect was a consequence of modulation of the resident colonic bacterial ‘flora’. His conviction could not be substantiated because of the lack of tools necessary to address the issue rigorously in that era. A century later, advanced technology has established the role of the human microbiota in health and disease. Emerging information is leading to a fundamentally revised understanding of many aspects of human development and disease that takes into account the role of the microbiota. This chapter addresses current knowledge of the relationship of the microbiome to human ageing, and outlines the prospects for monitoring and modulating the gut microbiota to promote healthy ageing.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.