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Inflammation and its role in ageing and disease 

Inflammation and its role in ageing and disease
Chapter:
Inflammation and its role in ageing and disease
Author(s):

Jintang Wang

and Sean X. Leng

DOI:
10.1093/med/9780198701590.003.0044
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date: 18 October 2019

Ageing is a complex process characterized by progressive loss of homeostasis and physiologic reserve with increased disease susceptibility and vulnerability to adverse health outcomes. It is often accompanied by a low-grade, systemic, unresolved, and smouldering chronic inflammation marked by 2–4-fold increase in circulating levels of multiple inflammatory mediators. This chapter begins with a brief discussion of the basic biology thought to drive chronic inflammation, and then proceeds to provide an overview of current evidence supporting significant contribution of age-related chronic inflammation to frailty and late-life functional decline, neurodegenerative diseases, cardiovascular diseases, and age-related metabolic diseases. It ends with a brief discussion of the anti-inflammatory properties of caloric restriction (CR) and physical exercise, suggesting the possibility of developing interventional strategies to mitigate age-related chronic inflammation and its adverse impact on the health and well being of older adults.

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