Show Summary Details
Page of

Age-related physiologic declines 

Age-related physiologic declines
Age-related physiologic declines

Elisa Fabbri

, Marco Zoli

, and Luigi Ferrucci

Page of

PRINTED FROM OXFORD MEDICINE ONLINE ( © Oxford University Press, 2022. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 01 July 2022

‘How and why living organisms age?’ This question has puzzled and challenged philosophers and scientists for centuries. Ageing can be defined as a progressive loss of anatomic and physiological integrity across multiple systems and organs, leading to impaired function and higher vulnerability to adverse health outcomes and death. Although the biological mechanisms that trigger and accelerate ageing are still not understood, enormous steps forward in delineating the effects of ageing has been made in recent years. Ageing induces morphological and physiological changes across multiple organs and systems, which result in progressive loss of resilience, increased vulnerability to stressors, disease susceptibility, and development of physical and cognitive frailty, disability, and adverse outcomes.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.