- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing
- Chapter 161 Healthy ageing phenotypes and trajectories
- Chapter 162 Empowerment of the ageing population: a contribution to active ageing
- Chapter 163 Midlife risk factors of diseases and geriatric syndromes
- Chapter 164 Optimizing physical activity across the lifespan
- Chapter 165 Nutrition, ageing, and longevity
- Chapter 166 Optimizing cognition in older adults: lifestyle factors, neuroplasticity, and cognitive reserve
- Chapter 167 Preserving mental health and well-being
- Chapter 168 Clinical translation of interventions that target ageing: towards a longevity dividend
- Chapter 169 Driving, transportation, and mobility in the older adult
- Chapter 170 Nanosciences and the medicine of ageing
- Chapter 171 Gerontechnology
- Chapter 172 Personalized medicine for older adults
- Chapter 173 What next for geriatric medicine?
(p. 1297) Clinical translation of interventions that target ageing: towards a longevity dividend
- Chapter:
- (p. 1297) Clinical translation of interventions that target ageing: towards a longevity dividend
- Author(s):
Allyson K. Palmer
and James L. Kirkland
- DOI:
- 10.1093/med/9780198701590.003.0168
Exciting advances have been made recently in understanding the mechanistic underpinnings of ageing. Mounting evidence suggests that progression of ageing changes can be modulated. Interventions that extend healthspan and lifespan in model organisms have been developed. The time is approaching for translation of these interventions into clinical treatments. By targeting fundamental ageing mechanisms, it may be possible to delay, prevent, or alleviate chronic diseases as a group, rather than individually, and enhance healthspan. Such a compression of morbidity would have profound clinical and economic benefits, with reductions in life-years spent with chronic disease and age-related dysfunction. However, barriers remain, including lack of clinical and regulatory paradigms for translating agents that target fundamental ageing processes into clinical interventions, and a shortage of personnel trained to do so. Here we consider research findings that support the potential value of translational ageing research and strategies to move these findings from bench to bedside.
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- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing
- Chapter 161 Healthy ageing phenotypes and trajectories
- Chapter 162 Empowerment of the ageing population: a contribution to active ageing
- Chapter 163 Midlife risk factors of diseases and geriatric syndromes
- Chapter 164 Optimizing physical activity across the lifespan
- Chapter 165 Nutrition, ageing, and longevity
- Chapter 166 Optimizing cognition in older adults: lifestyle factors, neuroplasticity, and cognitive reserve
- Chapter 167 Preserving mental health and well-being
- Chapter 168 Clinical translation of interventions that target ageing: towards a longevity dividend
- Chapter 169 Driving, transportation, and mobility in the older adult
- Chapter 170 Nanosciences and the medicine of ageing
- Chapter 171 Gerontechnology
- Chapter 172 Personalized medicine for older adults
- Chapter 173 What next for geriatric medicine?