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Clinical translation of interventions that target ageing: towards a longevity dividend 

Clinical translation of interventions that target ageing: towards a longevity dividend
Chapter:
Clinical translation of interventions that target ageing: towards a longevity dividend
Author(s):

Allyson K. Palmer

and James L. Kirkland

DOI:
10.1093/med/9780198701590.003.0168
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date: 22 January 2022

Exciting advances have been made recently in understanding the mechanistic underpinnings of ageing. Mounting evidence suggests that progression of ageing changes can be modulated. Interventions that extend healthspan and lifespan in model organisms have been developed. The time is approaching for translation of these interventions into clinical treatments. By targeting fundamental ageing mechanisms, it may be possible to delay, prevent, or alleviate chronic diseases as a group, rather than individually, and enhance healthspan. Such a compression of morbidity would have profound clinical and economic benefits, with reductions in life-years spent with chronic disease and age-related dysfunction. However, barriers remain, including lack of clinical and regulatory paradigms for translating agents that target fundamental ageing processes into clinical interventions, and a shortage of personnel trained to do so. Here we consider research findings that support the potential value of translational ageing research and strategies to move these findings from bench to bedside.

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