- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing
- Chapter 161 Healthy ageing phenotypes and trajectories
- Chapter 162 Empowerment of the ageing population: a contribution to active ageing
- Chapter 163 Midlife risk factors of diseases and geriatric syndromes
- Chapter 164 Optimizing physical activity across the lifespan
- Chapter 165 Nutrition, ageing, and longevity
- Chapter 166 Optimizing cognition in older adults: lifestyle factors, neuroplasticity, and cognitive reserve
- Chapter 167 Preserving mental health and well-being
- Chapter 168 Clinical translation of interventions that target ageing: towards a longevity dividend
- Chapter 169 Driving, transportation, and mobility in the older adult
- Chapter 170 Nanosciences and the medicine of ageing
- Chapter 171 Gerontechnology
- Chapter 172 Personalized medicine for older adults
- Chapter 173 What next for geriatric medicine?
(p. 1243) Healthy ageing phenotypes and trajectories
- Chapter:
- (p. 1243) Healthy ageing phenotypes and trajectories
- Author(s):
Sebastiano Collino
, Blandine Comte
, Estelle Pujos Guillot
, Claudio Franceschi
, Antonio Nuñez Galindo
, Loïc Dayon
, and Martin Kussmann
- DOI:
- 10.1093/med/9780198701590.003.0161
The concept of healthy ageing today is linked to the efforts of maintaining physical and mental independence, and to prevent the decline of physiological functions that are mandatory to guarantee a good quality of life. Yet, an individual’s ageing trajectory and underlying mechanisms are multifaceted and still far from understood. Hence, there is an urgent need for the further development of ageing phenotypes that can be utilized in the identification of biomarkers to characterize and predict biological age, taking into account the multiple dimensions of ageing. New technologies, often termed ‘systems biology’ approaches, are being increasingly applied to research focused on ageing populations. These technologies should enable investigators, and eventually clinicians, to (a) understand ageing metabolism in a more detailed and specific way; (b) enable the phenotypic characterization of many age-related disorders including chronic disease states; and (c) stratify older adults and the multiple comorbid conditions that may impact them.
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- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing
- Chapter 161 Healthy ageing phenotypes and trajectories
- Chapter 162 Empowerment of the ageing population: a contribution to active ageing
- Chapter 163 Midlife risk factors of diseases and geriatric syndromes
- Chapter 164 Optimizing physical activity across the lifespan
- Chapter 165 Nutrition, ageing, and longevity
- Chapter 166 Optimizing cognition in older adults: lifestyle factors, neuroplasticity, and cognitive reserve
- Chapter 167 Preserving mental health and well-being
- Chapter 168 Clinical translation of interventions that target ageing: towards a longevity dividend
- Chapter 169 Driving, transportation, and mobility in the older adult
- Chapter 170 Nanosciences and the medicine of ageing
- Chapter 171 Gerontechnology
- Chapter 172 Personalized medicine for older adults
- Chapter 173 What next for geriatric medicine?