Show Summary Details
Page of

The diagnosis of Alzheimer’s disease: assessment and criteria 

The diagnosis of Alzheimer’s disease: assessment and criteria
Chapter:
The diagnosis of Alzheimer’s disease: assessment and criteria
Author(s):

Bruno Dubois

, Massimo Filippi

, and Gunhild Waldemar

DOI:
10.1093/med/9780198701590.003.0126
Page of

PRINTED FROM OXFORD MEDICINE ONLINE (www.oxfordmedicine.com). © Oxford University Press, 2016. All Rights Reserved. Under the terms of the licence agreement, an individual user may print out a PDF of a single chapter of a title in Oxford Medicine Online for personal use (for details see Privacy Policy and Legal Notice).

date: 23 August 2019

Alzheimer’s disease (AD) is the most prevalent form of dementia: it accounts for 70% of cases of progressive cognitive impairment in aged individuals, age being the single most important risk factor. The disease is linked with ageing, but it is not due to ageing, as exemplified by early onset cases. AD has characteristic clinical features, usually including various combinations of memory impairment, executive deficits, impaired instrumental functions, and behavioural/neuropsychiatric disturbances that may interfere with functioning of activity of daily living. Detailed neuropsychological testing with standardized assessment is required for quantifying the deficits of AD and may aid distinguishing AD from other degenerative dementias. The clinical diagnosis of AD has traditionally required exclusion of alternative explanations for cognitive decline using blood testing and brain neuroimaging techniques. A new conceptual framework based on pathophysiological biomarkers has been recently proposed that includes the prodromal (predementia) stage in the diagnostic algorithm.

Access to the complete content on Oxford Medicine Online requires a subscription or purchase. Public users are able to search the site and view the abstracts for each book and chapter without a subscription.

Please subscribe or login to access full text content.

If you have purchased a print title that contains an access token, please see the token for information about how to register your code.

For questions on access or troubleshooting, please check our FAQs, and if you can't find the answer there, please contact us.