- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Chapter 121 Normal cognition and ageing: structure, function, and cognitive reserve
- Chapter 122 Epidemiology of Alzheimer’s disease: a relevant challenge for long-term follow-up of a population-based cohort
- Chapter 123 Cognitive impairment—risk factors and prevention
- Chapter 124 Neuropsychological evaluation of cognition
- Chapter 125 Mild cognitive impairment
- Chapter 126 The diagnosis of Alzheimer’s disease: assessment and criteria
- Chapter 127 Assessment and diagnosis of the non-Alzheimer dementias
- Chapter 128 Pharmacological interventions in mild cognitive impairment and dementia
- Chapter 129 Non-pharmacologic behavioural activity interventions to prevent dementia
- Chapter 130 Management of comorbidities in dementia patients
- Chapter 131 Evidence-based management of behavioural and psychological symptoms of dementia
- Chapter 132 Caregivers in dementia: role and empowerment
- Chapter 133 A new model of care for patients with dementia: the Japanese initiative for dementia care
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing
(p. 971) Mild cognitive impairment
- Chapter:
- (p. 971) Mild cognitive impairment
- Author(s):
Pieter Jelle Visser
, Nienke Legdeur
, Mara ten Kate
, and Daniela Bertens
- DOI:
- 10.1093/med/9780198701590.003.0125
The concept of mild cognitive impairment (MCI) has been introduced to describe cognitive impairment in non-demented subjects. Subjects with MCI are of major clinical importance because they have an increased risk to develop dementia. MCI is a frequent condition with a prevalence of 10–20% in the elderly population. Alzheimer’s disease is the most common cause, but any somatic, neurological, or psychiatric disorder and drug that influence brain functioning could cause it as well. A clinical assessment can identify several of the underlying causes and biomarkers may also be useful. Treatment is available for some of the underlying causes of MCI. The development of novel biomarkers, such as tau PET, and novel treatments may increase opportunities to diagnose the underlying pathology and give disease-specific treatments in the future.
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- Section 1 Ageing population and policy
- Section 2 Key concepts in care of older adults
- Section 3 Principles and organization of care
- Section 4 Age-related biological changes, altered physiology, and vulnerability to diseases and chronic conditions
- Section 5 Geriatric syndromes in clinical practice
- Section 6 Nutrition and metabolism
- Section 7 Mobility disorders: prevention, impact, and compensation
- Section 8 Infections in older adults: epidemiology, pathophysiology, diagnosis, and management
- Section 9 Cancer: epidemiology, pathophysiology, diagnosis, and management
- Section 10 Vascular diseases: epidemiology, pathophysiology, diagnosis, and management
- Section 11 Neurological disorders: epidemiology, pathophysiology, diagnosis, and management
- Section 12 Cognitive decline and dementia in older adults: epidemiology, pathophysiology, diagnosis, and management
- Chapter 121 Normal cognition and ageing: structure, function, and cognitive reserve
- Chapter 122 Epidemiology of Alzheimer’s disease: a relevant challenge for long-term follow-up of a population-based cohort
- Chapter 123 Cognitive impairment—risk factors and prevention
- Chapter 124 Neuropsychological evaluation of cognition
- Chapter 125 Mild cognitive impairment
- Chapter 126 The diagnosis of Alzheimer’s disease: assessment and criteria
- Chapter 127 Assessment and diagnosis of the non-Alzheimer dementias
- Chapter 128 Pharmacological interventions in mild cognitive impairment and dementia
- Chapter 129 Non-pharmacologic behavioural activity interventions to prevent dementia
- Chapter 130 Management of comorbidities in dementia patients
- Chapter 131 Evidence-based management of behavioural and psychological symptoms of dementia
- Chapter 132 Caregivers in dementia: role and empowerment
- Chapter 133 A new model of care for patients with dementia: the Japanese initiative for dementia care
- Section 13 Mental health of older adults
- Section 14 Management of common medical conditions: epidemiology, pathophysiology, diagnosis, and management
- Section 15 Palliative medicine and end-of-life care
- Section 16 Healthy ageing